| Acronym | Meaning |
 | MRF | Maintenance Responsibility File |
| MRF | Maximum Retarding Force |
| MRF | Measurements/Stimuli Request Form |
| MRI | Measurement Requirements And Interface |
| MRIR | Medium Resolution Infrared Radiometer |
| MRL | Manipulator Retention Latch |
| MRL | Manipulator Retention Latch |
| MRL | Manipulator Retention Latches |
| MRL | Manipulator Retention Lock |
| MRL | Material Requirements List |
| MRR | Mission Reconfiguration Request |
| MRS | Management Review System |
| MRTC | Multiple Real-Time Commands |
| MS | Machine Screw |
| MS | Machine Steel |
| MS | Margin Of Safety |
| MS | Mass Spectrometer |
| MS | Master Switch |
| MS | Material Specification |
| MS | Mating Sequence And Control |
| MS | Milestone |
| MS | Military Standard (Parts Designation) |
| MS | Millisecond |
| MS | Mission SPecialist |
| MS | Mission Station |
| MS | Multistring |
| MS/MS | Material Science And Manufacturing In Space |
| MSA | Material Service Area |
| MSA | Minimum Surface Area |
| MSA | MSA-1 |
| MSAD | Materials Summary Acceptance Document |
| MSB | Most Significant Bit |
| MSBLS | Microwave Scan Beam Landing System |
| MSBLS | Microwave Scanning Beam Land Station |
| MSBLS | Microwave Scanning Beam Landing System |
| MSBLS-GS | MSBLS Ground Station |
| MSC | Manned Spacecraft Center (changed To JSC) |
| MSC | Master Sequence Controller |
| MSC | Materials Service Center |
| MSC | Military Sealift Command |
| MSC | Moding Sequencing And Control |
| MSCR | Measurement/Stimuli Change Request |
| MSD | MARS Supplemental Data |
| MSDS | Multispectral Scanner And Data System |
| MSE | Maintenance Support Equipment |
| MSE | Measuring And Stimuli Equipment |
| MSE | Mechanical Support Equipment |
| MSE | Medical Support Equipment |
| MSE | Mission Staff Engineer |
| MSEC | Master Separation Events Controller |
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