| Acronym | Meaning |
 | FOC | Full Operational Capability |
| FOD | Flight Operations Directorate (JSC) |
| FOE | Flight Operations Engineer |
| FOF | First Operational Flight |
| FOF | First Orbital Flight |
| FOF | Flight Operations Facilities |
| FOIH | Flight Operations Integration Handbook |
| FOM | R Flight Operations Management Room |
| FOP | Flight Operations Panel |
| FOP | Flight Operations Plan |
| FOP | Follow On Production |
| FOPG | Flight Operations Planning Group |
| FOPP | Follow On Parts Production |
| FOPS | Flight Operations Planning Schedule |
| FOR | Flight Operations Review |
| FOR | Force |
| FORTRAN | Formula Translation |
| FOS | Flight Operations Support |
| FOSDIC | Film Optical Sensing Device For Input To Computers |
| FOSO | Flight Operations Scheduling Officer |
| FOSP | Flight Operations Support Personnel |
| FOST | Flight Operations SUPPOrt Team |
| FOT | Flight Operations Team |
| FOV | Field Of View (Vision) |
| FOV | First Orbital Vehicle |
| FP | Fine Pointing |
| FP | Fixed Point |
| FP | Flight Plan |
| FP | Freezing Point |
| FP | Fuel Pressure |
| FP | Function Path |
| FPB | Fuel Preburner |
| FPBOV | Fuel Preburner And Oxidizer Valve |
| FPC | Fluids Pressure Control |
| FPC | Forward Power Controller |
| FPCA | Forward Power Control Assembly |
| FPCA | Forward Power Controller Assembly |
| FPE | Functional Program Element |
| FPEG | Fast Pulse Electron Gun |
| FPHB | Flight Procedures Handbook |
| FPIF | Fixed Price Incentive Fee |
| FPL | Full Power Level |
| FPL | Full Power Load |
| FPM | Feet Per Minute |
| FPM | Folding Platform Mechanism |
| FPOV | Fuel Preburner Oxidizer Valve |
| FPP | Freon Pump Package |
| FPPR | Fixed Price With Price Revision |
| FPR | Flight Performance Reserve |
| FPS | Feet Per Second |
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