| Acronym | Meaning |
 | EAFB | Edwards Air Force Base |
| EAFB | Edwards Air Force Base |
| EAFB | Elgin Air Force Base |
| EAFB | Ellington Air Force Base |
| EAM | Electrical Accounting Machine |
| EAR | Engineering AnalYsis Report |
| EAS | Equivalent Air Speed |
| EAS | Equivalent Airspeed |
| EAT | Environmental Acceptance Test |
| EB | Electronic Beam |
| EB | Emergency Box |
| EBC | Emulated Buffer COMPuter |
| EBCDC | Extended Binary Coded Decimal |
| EBD | Eyeballs Down (+GZ) |
| EBI | Eyeballs In (+GX) |
| EBL | Eyeballs Left (+GY) |
| EBO | Eyeballs Out (-GX) |
| EBR | Eyeballs Right (-GY) |
| EBS | Emergency Breathing Subsystem |
| EBU | Eyeballs Up (-GZ) |
| EBW | Electron Beam Welding |
| EBW | Exploding Bridge Wire |
| EC | Element Contractor |
| EC | Engine Control |
| EC | Engine Cutoff |
| EC | Essentiality Code |
| EC | Events Controller |
| EC | Events Coupler |
| EC | Experiment Computer |
| ECA | Electronics Control Assembly |
| ECA | Engineering Change Analysis |
| ECA | Epoxy Curing Agent |
| ECAS | Experiment Computer Application Software |
| ECB | Engineering Change Board |
| ECB | Event Control Block |
| ECB | Events Control Buffer |
| ECC | Engineering Change Control |
| ECC | Engineering Critical Component |
| ECCB | Engineering Change Control Board |
| ECD | Engineering Control Drawing |
| ECD | Estimated Completion Date |
| ECEP | Experiment Checkout Equipment Processor |
| ECF | Element Charge Factor |
| ECF | Equivalency Capability File |
| ECG | Electrocardiogram |
| ECG | Electrocardiograph |
| ECI | Earth Centered Inertia (inertials) |
| ECIO | Experiment Computer Input/Output |
| ECL | Entry Closed Loop |
| ECLS | Environmental Control And Life Support |
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