| Acronym | Meaning |
 | OUP | OFS UPlink Processor |
| OUT | Orbiter Utilities Tray |
| OUT | Outlet |
| OUT | Output |
| OUTBD | Outboard |
| OV | Orbiter Vehicle |
| OV | Orbiter Vehicle |
| OV | Oxygen Vent |
| OVBD | Overboard |
| OVCO | Operational Voice Communication Office |
| OVF | Overfill |
| OVFL | Overf Low |
| OVHD | Overhead |
| OVHT | Overheat |
| OVI | Operational Validation Inspection |
| OVLD | Overload |
| OVRD | Override |
| OVS | Operational Voice System |
| OVV | Overvoltage |
| OW | Optical Window |
| OWD | One-Way Doppler |
| OWDE | One-Way Doppler Extraction |
| OWF | OPtimum Working Frequency |
| OX | Oxidizer |
| OXD | Oxide |
| OXDZR | Oxidizer |
| OXID | Oxidizer |
| OXY | Oxygen |
| OZ | Ounce |
| OZ | Ozone |
| P | Pallet (Spacelab) |
| P | Period |
| P | Pilot |
| P | Pitch |
| P | Pole |
| P | Pressure |
| P | Primary |
| P | Prime |
| P | Roll Rate (Angular Rate) |
| P&FS | Particles And Fields Subsatellite |
| P&I | Performance And Interface (Specification) |
| P&M | Performance Monitor |
| P&M | Phase Modulation (Modulated) |
| P&M | Planetary Mission |
| P&M | Preventive Maintenance |
| P&M | Processes And Materials |
| P&M | Program Milestone |
| P&M | Pulse Modulation |
| P&R | Performance And Resources |
| P&SM | Procurement And Subcontract Management |
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