| Acronym | Meaning |
| DG | Data General |
| DG | Diesel Generator |
| DGC | Division Of Grants And Contracts |
| DGPS | Differential Global Positioning System |
| DH&HS | Director Of Health & Human Services |
| DHC | Data Handling Center |
| DHEW | Department Of Health |
| DHR | Director Of Human Resources |
| DHS | Data Handling Services |
| DIA | Direct-interaction Approximation |
| DIA | Denver International Airport |
| DIA | Defense Intelligence Agency |
| DIAL | Differential Absorption Lidar |
| DIB | Directory Information Base |
| DIB | Disabilities Issues Board |
| DIC | Dissolved Inorganic Carbon |
| DIC | Defense Intelligence College |
| DICOMED | Online Graphics Recorder Used At NCAR For Producing Microfilm And Microfiche Output |
| DID | Data Item Description |
| DIF | Data Interface Facility |
| DIF | Directory Interchange Format |
| DIFAX | Digital Facsimile Map |
| DIG | DOE Interaction Group |
| DIMES | DIstributed MEtadata System |
| DIP DUAL IN-LINE PACKAGE | N/A |
| DIPS DMS IMAGE PROCESSING SYSTEM | N/A |
| DIR | Director's Office |
| DIRC | DOE Internal Review Committee |
| DIRP | DOE Internal Review Panel |
| DIS | Data Information System |
| DIS | Data Interface System |
| DIS | Defense Intelligence Service |
| DISA | Defense Information Systems Agency |
| DISN | Defense Information Systems Network |
| DLA | Defense Logistics Agency |
| DLD | Digital Loran Dropwindsonde |
| DLESE | Digital Library For Earth System Education |
| DLPDU | Data Link Protocol Data Unit |
| DLR | Deutsche Zentrum Fur Luft-und Raumfarht |
| DLS | Dynamic Limb Sounder |
| DLT | Digital Linear Tape |
| DM | Data Management |
| DMA | Defense Mapping Agency |
| DMA | Directory Of Military Application |
| DMAIAGS | Defense Mapping Agency Inter-American Geodetic Survey |
| DMDS | DiMethyDiSulfide |
| DME | Distance-measuring Equipment |
| DMI | Danish Meteorological Institute |
| DML | RF Dimensional Metrology Laboratory |
| DMMR | Distributed-Memory Microprocessor Systems |