| Acronym | Meaning |
 | SPOC | Shuttle Payload Operations Contractor |
| SPOM | STS Planning And Operations Management |
| SPP | Simulation Planning Panel |
| SPP | Solar Physics Payload |
| SPPIL | Shuttle Preferred Pyrotechnic Items List |
| SPPL | Spare Parts Provisioning List |
| SPPP | Spacelab Payloads Processing Project |
| SPR | Software Problem Report |
| SPR | Subcontractor Performance Review |
| SPRAG | STS Payloads Requirements And AnalYsis Group |
| SPRT | Sequential Probability Ratio Test |
| SPS | Samples Per Second |
| SPS | Secondary Propulsion System |
| SPS | Service Propulsion Subsystem |
| SPS | Shuttle Procedures Simulator |
| SPS | Solar Power Satellite |
| SPS | Statement Of Prior Submission |
| SPT | Steering Position Transducer |
| SPT | Support |
| SPTD | Supplemental Provisioning Technical Documentation |
| SPVPF | Shuttle Payload Vertical Processing Facility |
| SQ | FtSquare Feet |
| SR | Scan Ratio |
| SR | Shift Register |
| SR | Standard Repair |
| SR | Statement Of Requirements |
| SR | Status Register |
| SR | Status Report |
| SR | Status Review |
| SR | Sunrise |
| SR | Support Request |
| SR | Support Room |
| SR&Q | Safety |
| SR&QA | Safety |
| SRA | Spin Reference Axis |
| SRA | Support Requirements Analysis |
| SRAG | Space Radiation Analysis Group |
| SRB | Solid Rocket Booster |
| SRB | Solid Rocket Booster |
| SRBAB | SRB Assembly Building |
| SRBDF | SRB Disassembly Facility |
| SRBPF | Solid Rocket Booster Processing Facility |
| SRC | Sample Return Container |
| SRCB | Software Requirements Change Board |
| SRCB | Software Requirements Control Board |
| SRCBD | Software Requirements Change Board Directive |
| SRCBD | Software Requirements Control Board Directive |
| SRCH | Search |
| SRD | Shuttle Requirements Definition |
| SRD | Shuttle Requirements Document |
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