| Acronym | Meaning |
| DMPA | (U.S.) Defense Medical Programs Activity |
| DMPFC | DorsoMedial PreFrontal Cortex |
| DMRB | Design Manual For Roads And Bridges |
| DMS | U.S. Defense Message System |
| DMSO | U.S. Defense Modeling & Simulation Office (dim-so) |
| DMSP | U.S. Defense Meteorological Satellite Program |
| DMT | Dimethyltryptamine |
| DMU | Diesel Multiple Unit - A Method Of Connecting Self-propelled Railway Vehicles Together To Form A Train Under The Control Of One Driver. |
| DMV | Department Of Motor Vehicles |
| DMZ | DeMilitarized Zone |
| DNA | U.S. Defense Nuclear Agency - DeoxyriboNucleic Acid - Douglas No?l Adams |
| DNAW | Day Night All Weather |
| DND | Department Of National Defence (Canada) - Do Not Disturb |
| DNDI | Drugs For Neglected Diseases Initiative |
| DNDO | U.S. Domestic Nuclear Detection Office |
| DNK | Denmark (ISO 3166 Trigram) |
| DNM | Defence Nuclear Material |
| DNR | Do Not Resuscitate |
| DO | Dominica (FIPS 10-4 Country Code) - Dominican Republic (ISO 3166 Digram) -Doctor Of Osteopathy |
| DOA | Dead On Arrival - Dead Or Alive |
| DOB | Date Of Birth |
| DOD | U.S. Department Of Defense |
| DODAF | U.S. Department Of Defense Architectural Framework |
| DODD | U.S. Department Of Defense Directive |
| DODEA | (U.S.) Department Of Defense Education Activity |
| DOE | U.S. Department Of Energy |
| DOHC | Dual-OverHead-Cam Engine |
| DOI | Digital Object Identifier - U.S. Department Of The Interior |
| DOM | Deo Optimo Maximo (Latin |
| DOMS | (U.S.) Director Of Military Support |
| DOP | Dominican Peso (ISO 4217 Currency Code) |
| DORA | Defence Of The Realm Act |
| DOS | Denial Of Service (DoS |
| DOT | Department Of Transportation (U.S. Federal Or State) |
| DOTD | Deal Of The Day (marketing Gimmick) |
| DOTMLPF | Doctrine |
| DOW | Died Of Wounds |
| DP | Decision Point - Dynamic Programming |
| DP | Division De Production (Algerian Petroleum Company) |
| DPA | UK Defence Procurement Agency |
| DPCO | Double-Pole Change Over |
| DPDT | Double-Pole Double-Throw |
| DPICM | Dual-Purpose Improved Conventional Munition |
| DPKO | UN Department For Peacekeeping Operations |
| DPMO | (U.S.) Defense Prisoner Of War/Missing Personnel Office |
| DPPDB | Digital Point Positioning Database |
| DPRE | Displaced Person Or Refugee (plural Displaced Persons And Refugees) |
| DPRK | Democratic People's Republic Of Korea |
| DPST | Double-Pole Single-Throw |
| DQ | Dairy Queen -Jarvis Island (FIPS 10-4 Country Code) |