| Acronym | Meaning |
 | USDI | United States Department Of The Interior |
| USDOE | United States Department Of Energy |
| USDRE | (U.S.) Under-Secretary Of Defense For Research And Engineering (1978?1986) |
| USEC | United States Enrichment Corporation |
| USFL | United States Football League |
| USFWS | United States Fish And Wildlife Service |
| USGS | United States Geological Survey |
| USIA | United States Information Agency |
| USJFCOM | United States Joint Forces Command |
| USMC | United States Marine Corps |
| USN | United States Navy |
| USNA | United States National Arboretum - United States Naval Academy |
| USNB | United States Naval Base |
| USNG | United States National Grid |
| USNH | United States Naval Hospital |
| USNI | United States Naval Institute |
| USNO | U.S. Naval Observatory |
| USNOFS | U.S. Naval Observatory Flagstaff Station |
| USNP | United States Newspaper Program |
| USNR | United States Navy Reserve |
| USNS | United States Naval Ship |
| USNY | University Of The State Of New York (usually Pronounced Use-knee) |
| USNZ | University Sport New Zealand |
| USPS | United States Postal Service |
| USPTO | United States Patent And Trademark Office |
| USR | Universal System Resources (/usr |
| USS | United States Ship (sometimes Meaningless; See Star Trek) |
| USSPACECOM | United States Space Command |
| USSR | Union Of Soviet Socialist Republics |
| UST | Underground Storage Tank |
| USTRANSCOM | United States Transportation Command |
| UT | Universal Time |
| UTEP | University Of Texas At El Paso (pronounced You-tep) |
| UTM | Universal Transverse Mercator (geographical Co-ordinate System) |
| UU | Unitarian Universalism - University Of Utah - Unseen University |
| UUA | Unitarian Universalist Association |
| UUB | Ununbium (temporary Superheavy Chemical Element Name) |
| UUID | Universally Unique Identifier (see Also GUID) |
| UUV | Unmanned Underwater Vehicle |
| UV | Burkina Faso (FIPS 10-4 Country Code; From Upper Volta) -ultraviolet |
| UW | University Of Washington |
| UWO | University Of Western Ontario |
| UWT | Under Water Telephone |
| UWTG | Under Water Tug |
| UXO | Unexploded Ordnance |
| UY | Uruguay (ISO 3166 And FIPS 10-4 Country Code Digram) |
| UYU | Uruguayan Peso Uruguayo (ISO 4217 Currency Code) |
| UZ | Uzbek Language (ISO 639-1 Code) |
| UZ | Uzbekistan (ISO 3166 And FIPS 10-4 Country Code Digram) |
| UZB | Uzbek Language (ISO 639-2 Code) |
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