| Acronym | Meaning |
 | HOSC | Huntsville Operations Support Center |
 | HP | Handling Procedure |
 | HP | HewlettPackard |
 | HPF | Horizontal Processing Facility (O&C) |
 | HPFT | High-pressure Fuel Turbopump |
 | HPFTP | High Pressure Fuel Turbopump |
 | HPG | High Pressure Gas |
 | HPGS | High Pressure Gas System |
 | HPI | High Performance Insulation |
 | HPOP | High Pressure Oxidizer Pump |
 | HPOT | High Pressure Oxidizer Turbopump |
 | HPOT | High-pressure Oxidizer Turbopump |
 | HPOTP | High Pressure Oxidizer Turbopump |
 | HPPF | Horizontal Payloads Processing Facility |
 | HPR | Hydrogen Pressure Regulator |
 | HPRV | Hydrogen Pressure Relief Valve |
 | HPS | Hydraulic Power SYstem |
 | HPT | High Pressure Test |
 | HPU | Hydraulic Power Unit |
 | HPU | Hydraulic Power Unit |
 | HPV | High Pressure Valve |
 | HQ | Headquarters (HDQ Preferred) |
 | HQR | Handling Qualities Rating (Cooper-Harper) |
 | HR | Historical Record |
 | HR | Hour |
 | HRAA | High Rate Acquisition Assembly |
 | HRC | Hasselblad Reflex Camera |
 | HRD | High Rate Dosimeter |
 | HRD | High-rate Dosimeter |
 | HRDA | High Rate Data Assembly |
 | HRDM | High Rate Demultiplexer |
 | HRDR | High Rate Digital Recorder |
 | HRDS | High Rate Data Station |
 | HRIR | High Resolution Infrared Radiometer |
 | HRL | Horizontal Reference Line |
 | HRM | High Rate Multiplexer |
 | HRM | High-rate Multiplexer |
 | HRPS | Hazard Reduction Precedence Sequence |
 | HRS | Hours |
 | HRSI | High Temperature Reusable Surface Insulation |
 | HRSI | High-temperature Reusable Surface Insulation |
 | HRT | High Resolution Tracker |
 | HS | Heat Shield |
 | HS | High Speed |
 | HS | Horizon Sensor |
 | HS-C | Hamilton Standard CO Absorbent Material |
 | HSC | Hardware/Software Coordination |
 | HSCU | Hydraulic SUPPly And Checkout Unit |
 | HSD | Hamilton Standard Division |
 | HSD | High Speed Data |