| Acronym | Meaning |
 | HOSC | Huntsville Operations Support Center |
| HP | Handling Procedure |
| HP | HewlettPackard |
| HPF | Horizontal Processing Facility (O&C) |
| HPFT | High-pressure Fuel Turbopump |
| HPFTP | High Pressure Fuel Turbopump |
| HPG | High Pressure Gas |
| HPGS | High Pressure Gas System |
| HPI | High Performance Insulation |
| HPOP | High Pressure Oxidizer Pump |
| HPOT | High Pressure Oxidizer Turbopump |
| HPOT | High-pressure Oxidizer Turbopump |
| HPOTP | High Pressure Oxidizer Turbopump |
| HPPF | Horizontal Payloads Processing Facility |
| HPR | Hydrogen Pressure Regulator |
| HPRV | Hydrogen Pressure Relief Valve |
| HPS | Hydraulic Power SYstem |
| HPT | High Pressure Test |
| HPU | Hydraulic Power Unit |
| HPU | Hydraulic Power Unit |
| HPV | High Pressure Valve |
| HQ | Headquarters (HDQ Preferred) |
| HQR | Handling Qualities Rating (Cooper-Harper) |
| HR | Historical Record |
| HR | Hour |
| HRAA | High Rate Acquisition Assembly |
| HRC | Hasselblad Reflex Camera |
| HRD | High Rate Dosimeter |
| HRD | High-rate Dosimeter |
| HRDA | High Rate Data Assembly |
| HRDM | High Rate Demultiplexer |
| HRDR | High Rate Digital Recorder |
| HRDS | High Rate Data Station |
| HRIR | High Resolution Infrared Radiometer |
| HRL | Horizontal Reference Line |
| HRM | High Rate Multiplexer |
| HRM | High-rate Multiplexer |
| HRPS | Hazard Reduction Precedence Sequence |
| HRS | Hours |
| HRSI | High Temperature Reusable Surface Insulation |
| HRSI | High-temperature Reusable Surface Insulation |
| HRT | High Resolution Tracker |
| HS | Heat Shield |
| HS | High Speed |
| HS | Horizon Sensor |
| HS-C | Hamilton Standard CO Absorbent Material |
| HSC | Hardware/Software Coordination |
| HSCU | Hydraulic SUPPly And Checkout Unit |
| HSD | Hamilton Standard Division |
| HSD | High Speed Data |
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