| Acronym | Meaning |
 | ES | Experiment Segment |
 | ESA | Engineering SuPPly Area |
 | ESA | Engineering SuPPort Assembly |
 | ESA | European Space Agency |
 | ESA | European Space Agency |
 | ESA | ExPlosive Safe Area |
 | ESA | Explosive Safe Area (KSC) |
 | ESB | Essential Switching Box |
 | ESC | Escape |
 | ESCA | Electron Spectroscopy For Chemical Analysis |
 | ESCU | Extended Service And Cooling Umbilical |
 | ESD | Emergency Shutdown |
 | ESD | Experiment Systems Division |
 | ESDAC | European Space Data Center (Darmstadt |
 | ESDU | Event Storage And Distribution Unit |
 | ESE | Electrical Support Equipment |
 | ESE | Electronic SuPport Equipment |
 | ESE | EVA Support Equipment |
 | ESF | Explosive Safe Facility |
 | ESI | Electrical System Integration |
 | ESMC | Eastern Space And Missile Center (formerly AFETR) |
 | ESMC | ETR |
 | ESO | Event Sequence Override |
 | ESOC | European Space Operations Center |
 | ESOW | Engineering Statement Of Work |
 | ESP | Electroshock Protection |
 | ESP | Engine Service Platforms |
 | ESP | Experiment Sensing Platform |
 | ESPS | Experiment Segment Pallet Simulator |
 | ESR | Effective Sunrise |
 | ESR | Engineering Support Request |
 | ESRIN | European Space Research Institute |
 | ESRO | European Space Research Organization |
 | ESRO | European Space Research Organization |
 | ESS | Effective Sunset |
 | ESS | Environmental Support System |
 | ESS | Equipment Support Section |
 | ESS | Essential |
 | ESS | Essential |
 | ESS | Experiment Subsystem Simulator |
 | ESSA | Environmental Sciences Services Administration |
 | EST | Eastern Standard Time |
 | EST | Estimate(d) |
 | ESTA | Electronic System Test Equipment |
 | ESTA | Escape System Test Article |
 | ESTEC | European Space Research And Technology Center |
 | ESTEC | European Space Technology Center |
 | ESTL | Electronic Systems Test Laboratory |
 | ESV | Emergency Shutoff Valve |
 | ESVS | Escape Suit Ventilation System |