| Acronym | Meaning |
 | DDAS | Digital Data Acquisition System |
| DDC | Data Distribution Center |
| DDC | Defense Documentation Center |
| DDC | Digital Data Cell |
| DDD | Design Definition Document |
| DDD | Display Decoder Drive |
| DDDL | Digital Data Downlink |
| DDDU | Digital Decoder Driver Unit |
| DDI | Dedicated Display Indicator |
| DDI | Discrete Data Input |
| DDI | Discrete Digital Input |
| DDIS | Data Depository Index System |
| DDL | Data Downlink |
| DDM | Data Display Module |
| DDM | Data Display Monitoring |
| DDM | Discrete Data Management |
| DDMS | DOD Manager For Space Shuttle Support |
| DDO | Discrete Digital Output |
| DDP | Design Development Plan |
| DDP | Digital Data Processing (Processor) |
| DDPC | Digital Data Processing Center (Complex) |
| DDPF | Dedicated Display Processing Function |
| DDPS | Digital Data Processing System |
| DDR | Data Discrepancy Report |
| DDR | Design Development Record |
| DDR | Detail Design Review |
| DDS | Data Display System |
| DDS | Detailed Design Specification |
| DDS | Documentation Distribution System |
| DDT&E | Design |
| DDT&E | Design |
| DDT&E | Design |
| DDTF | Dynamic Docking Test Facility |
| DDTS | Dynamic Docking Test System |
| DDU | Data Display Unit |
| DDU | Decommutator Distribution Unit |
| DDU | Display Driver Unit |
| DDU | Display Driver Unit |
| DE | Design Engineering (KSC Dir.) |
| DE | Doppler Extractor |
| DE | Dynamics Explorer |
| DEA | Deployed Electronics Assembly |
| DEACT | Deactivate |
| DEC | Declination |
| DECL | Direct Energy Conversion Laboratory (JSC) |
| DECOM | Decommutate |
| DECR | Decrease |
| DECS | Civil Engineering Office At Vandenberg |
| DECU | Data Exchange Control Unit |
| DED | Dedicate |
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