| Acronym | Meaning |
 | CQD | R Critical Qualification Design Review |
| CR | Card Reader |
| CR | Certification Requirement |
| CR | Change Request |
| CR | Configuration Review |
| CR | Control Room |
| CR | Crew |
| CR/DIR | Change Request Directive |
| CRAS | Cost Reduction Alternative Study |
| CRB | Change Review Board |
| CRC | Contractor Recommended Code |
| CRC | Cost Reduction Curve |
| CRD | Change Request Disposition |
| CRDP | Computer Resources Development Plan |
| CRES | Corrosion Resistant Steel |
| CRG | Change Review Group |
| CRG | Correspondence Review Group |
| CRIS | Calibration Recall And Information System |
| CRISP | Computer Resources Integrated Support Plan |
| CRIT | Critical |
| CRM | Chemical Release Module |
| CRMD | Computer Resources Management Data |
| CRN | Cable Routing Rotation |
| CRN | Contract Revision Number |
| CRO | Cathode Ray Oscillograph(s) Or Oscilloscopes |
| CRP | Configuration Requirements Processing |
| CRPL | Cosmic Ray Physics Laboratory |
| CRR | Computer Run Report |
| CRR | Critical Requirements Review |
| CRS | C02 Reduction Subsystem |
| CRS | Course |
| CRS | Cross |
| CRSFD | Crossfeed |
| CRSI | Ceramic Reusable Surface Insulation |
| CRSVR | Crossover |
| CRT | Cathode Ray Tube |
| CRT | Cathode-Ray Tube |
| CRTG | Cartridge |
| CRW | Control Read/Write |
| CRYO | Cryogenic |
| CS | Change Status |
| CS | Checkout Station |
| CS | Common Set |
| CS | Consumables Status |
| CS | Control Segment |
| CS | Core Segment |
| CS | Crew Station |
| CS | Spacelab Operations Directorate |
| CS | STS Cargo Operations (KSC Directorate) |
| CSA | CYclic Strain Attenuator |
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