| Acronym | Meaning |
 | SPCU | Simulation Process Control Unit |
 | SPCW | StoredProgramCommandWord |
 | SPD | Speed |
 | SPD | Standard Practice Directive |
 | SPD | R Software Preliminary Design Review |
 | SPDB | Subsystem Power Distribution BC)x |
 | SPDBK | SpeedBrake |
 | SPDCI | Standard Payload Display And Control Interface |
 | SPE | Solid Polymer Electrolysis |
 | SPE | Static Phase Error |
 | SPEC | Specialist Function |
 | SPEC | Specification |
 | SPECT | Spectrometer |
 | SPEE | Special Purpose End Effector |
 | SPF | Single Point Failure |
 | SPF | Software Production Facility |
 | SPF | Spacelab Processing Facility |
 | SPFA | Single Point Failure Analysis |
 | SPFP | Single Point Failure Potential |
 | SPG | Signal Point Ground |
 | SPG | Single Point Ground |
 | SPHER | Spherical |
 | SPI | Surface Position Indicator |
 | SPI | Surface Position Indicator |
 | SPIAP | Shuttle/Payload Integration Activities Plan |
 | SPICE | Europe |
 | SPICE | SPacelab Payload Integration And Coordination In |
 | SPIDF | Support Planning Identification File |
 | SPIDPO | Office (JSC) |
 | SPIDPO | Shuttle Payload Integration And Development Progra |
 | SPIDPO | Shuttle Payload Integration And Development Program Office |
 | SPIF | Shuttle Payload Integration Facility |
 | SPIF | Standard Payload Interface Facility |
 | SPII | Shuttle Program Implementation Instruction |
 | SPIMS | Shuttle Program Information Management System |
 | SPKB | SpeedBrake |
 | SPKR | Speaker |
 | SPL | Scratch Pad Line |
 | SPL | Serialized Parts List |
 | SPL | Sound Pressure Level |
 | SPL | System Programming Language |
 | SPLX | Simplex |
 | SPLY | Supply |
 | SPM | SubsystemProjectManager |
 | SPMS | Special Purpose Manipulator System |
 | SPN | Shuttle Project Notice (KSC) |
 | SPND | Suspend |
 | SPO | Shuttle Projects Office |
 | SPO | Spare Parts Order |
 | SPO | SYstem Program Office |