| Acronym | Meaning |
 | SPCU | Simulation Process Control Unit |
| SPCW | StoredProgramCommandWord |
| SPD | Speed |
| SPD | Standard Practice Directive |
| SPD | R Software Preliminary Design Review |
| SPDB | Subsystem Power Distribution BC)x |
| SPDBK | SpeedBrake |
| SPDCI | Standard Payload Display And Control Interface |
| SPE | Solid Polymer Electrolysis |
| SPE | Static Phase Error |
| SPEC | Specialist Function |
| SPEC | Specification |
| SPECT | Spectrometer |
| SPEE | Special Purpose End Effector |
| SPF | Single Point Failure |
| SPF | Software Production Facility |
| SPF | Spacelab Processing Facility |
| SPFA | Single Point Failure Analysis |
| SPFP | Single Point Failure Potential |
| SPG | Signal Point Ground |
| SPG | Single Point Ground |
| SPHER | Spherical |
| SPI | Surface Position Indicator |
| SPI | Surface Position Indicator |
| SPIAP | Shuttle/Payload Integration Activities Plan |
| SPICE | Europe |
| SPICE | SPacelab Payload Integration And Coordination In |
| SPIDF | Support Planning Identification File |
| SPIDPO | Office (JSC) |
| SPIDPO | Shuttle Payload Integration And Development Progra |
| SPIDPO | Shuttle Payload Integration And Development Program Office |
| SPIF | Shuttle Payload Integration Facility |
| SPIF | Standard Payload Interface Facility |
| SPII | Shuttle Program Implementation Instruction |
| SPIMS | Shuttle Program Information Management System |
| SPKB | SpeedBrake |
| SPKR | Speaker |
| SPL | Scratch Pad Line |
| SPL | Serialized Parts List |
| SPL | Sound Pressure Level |
| SPL | System Programming Language |
| SPLX | Simplex |
| SPLY | Supply |
| SPM | SubsystemProjectManager |
| SPMS | Special Purpose Manipulator System |
| SPN | Shuttle Project Notice (KSC) |
| SPND | Suspend |
| SPO | Shuttle Projects Office |
| SPO | Spare Parts Order |
| SPO | SYstem Program Office |
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