| Acronym | Meaning |
| EPMA | Electron Probe Microanalysis |
| EPO | European Patent Organization |
| EPOCA | Environmental Project On Central America |
| EPQU | IFCC Expert Panel On Quantities And Units |
| EPR | East Pacific Rise |
| EPR | Electrochemical Potentiokinetic Reactivation |
| EPR | Electron Paramagnetic Resonance |
| EPR | Electrochem. Potentiodynamic Reactivation |
| EPR | Ethylene-propylene Rubber |
| EPRI | Electric Power Research Institute |
| EPROM | Erasable Programmable Read Only Memory |
| EPS | Emission Preprocessor System |
| EPS | Electric Power System |
| EPS | Expanded Polystyrene |
| EPS | Extracellular Polymeric Substances |
| EPS | Extrapyramidal Side Effect |
| EPSC | Excitatory Postsynaptic Current |
| EPSP | Excitatory Postsynaptic Potential |
| EPSRC | (United Kingdom) Engineering And Phys. Sciences Research Council |
| EPT | Exponential Perturbation Theory |
| EPTC | Extraction Procedure Toxicity Characteristic |
| EPTOX | Extraction Procedure Toxicity Test |
| EPV | Exclusion-principle Violating |
| EPW | Electron Plasma Wave |
| EPXMA | Electron Probe X-ray Microanalysis |
| EPZ | Emergency Planning Zone |
| EQA | External Quality Assessment |
| EQCIS | Electrochemical Quartz Crystal Impedance System |
| EQCM | Electrochemical Quartz Crystal Microbalance |
| EQE | Equivalent Quantum Efficiency |
| EQL | Estimated Quantitation Limit |
| EQMB | Electrochemical Quartz Microbalance |
| EQO | Environmental Quality Objective |
| EQPAC | Equatorial Pacific Study |
| EQS | Environmental Quality Standard |
| EQTC | Environmental Quality Target Concentration |
| ER | Endoplasmic Reticulum |
| ERA | Expedited Removal Action |
| ERA | Environmental Risk Assessment |
| ERACE | Electrical Remediation At Contaminated Environs |
| ERAD | Economic And Regulatory Analysis Division (OPPE) |
| ERAMS | Environmental Radiation Ambient Monitoring System |
| ERAQS | Eastern Regional Air Quality Study |
| ERAST | Environmental Research Aircraft And Science Technology |
| ERBE | Earth Radiation Budget Experiment |
| ERBS | Earth Radiation Budget Satellite |
| ERC | Emissions Reduction Credit |
| ERCAM | Emission Reduction And Cost Analysis Model |
| ERCC | Excision Repair Cross-complementing |
| ERCIM | European Research Consortium For Informatics And Mathematics |