| Acronym | Meaning |
| DSA | Dimensionally Stable Anode |
| DSA | Dynamic Simulated Annealing (for Electronic Structure In Liq.metals) |
| DSA | Dynamic Strain Aging |
| DSA-EOM | Dynamic Simulated Annealing-equations Of Motion (for Electronic Structures In Liq. Metals) |
| DSB | Double-strand Break |
| DSC | Differential Scanning Calorimetry |
| DSCCR | Diffractive Sudden-closed Coupled Rotation (for Mol.-surface Scattering Calcns.) |
| DSCEMS | Depth Selective Conversion Electron Moessbauer Spectroscopy |
| DSCF | Direct Self-consistent Field |
| DSDP | Deep Sea Drilling Project |
| DSDV | Dirac-Slater Discrete Variational |
| DSGE | Double Sine-gordon Equation (for Describing Excitations Such As Kinks And Solitons) |
| DSH | Dye-sensitized Heterojunction |
| DSID | Direct Sample Insertion Device |
| DSIMS | Dynamic Secondary Ion Mass Spectrometry |
| DSIP | Delta-sleep Inducing Peptide |
| DSITMS | Direct Sampling Ion Trap Mass Spectrometry |
| DSL | Domestic Substance List |
| DSLFS | Doppler-shift Laser Fluorescence Spectroscopy |
| DSMC | Direct Simulation Monte Carlo |
| DSMS | Depth-selective Moessbauer Spectroscopy |
| DSN | Deep Space Network |
| DSO-GF | Diagonal Second Order (approxn. To)-Green Function |
| DSP | Densified With Small Particles |
| DSP | Digital Signal Processor |
| DSPB | Distorted-wave Strong-potential Born (approxn.) |
| DSPC | Distearoyl Phosphatidylcholine |
| DSPEC | Dye-sensitized Photoelectrochemical |
| DSPES | Depth-selective Photoelectron Spectroscopy |
| DSPIL | Direct Solar Pumped Iodine Laser |
| DSPSE | Deep Space Probe Science Experiment |
| DSR | Dynamic Shape Roll |
| DSRNA | Double-stranded RNA |
| DSRT | Deep Sea Reversing Thermometer |
| DSS | Decision Support System |
| DSS | Deep Seismic Sounding |
| DSTD | Dynamic Surface Tension Detection |
| DSVI | Diluted Sludge Volume Index |
| DSW | Dirac Scattered-wave (often As SCF-X(alpha)-DSW Method) |
| DT | Dynamic Tear |
| DTA | Direct Toxicity Assessment (of Wastewater Discharges) |
| DTA | Differential Thermal Analysis |
| DTAB | Dodecyltrimethylammonium Bromide |
| DTBP | Di-tert-butyl Peroxide |
| DTC | Developmental Test Command [US Army] |
| DTC | Differential Thermal Calorimetry |
| DTCI | 3,3'-diethylthiacarbocyanine Iodide |
| DTDA | Differential Thermal Desorption Analysis |
| DTDMAC | Ditallowdimethylammonium Cation [surfactant] |
| DTDP | Ditridecyl Phthalate |