| Acronym | Meaning |
| LIBS | Laser-induced Breakdown Spectroscopy |
| LIBS | Ligand-induced Binding Sites |
| LIBWE | Laser-induced Backside Wet Etching |
| LICS | Laser-induced Continuum Structure |
| LID | Low Impact Developmentpar |
| LID | Lased Induced Desorption |
| LID | Laser Implant-deposition |
| LIDAR | Laser Intensity Direction And Ranging |
| LIDT | Laser-induced Damage Threshold |
| LIESA | Laser Induced Emission Spectral Analysis |
| LIESST | Light-induced Excited Spin State Trapping |
| LIF | Laser Induced Fluorescence |
| LIF | Leukemia Inhibitory Factor |
| LIFD | Laser-induced Fluorescence Detection |
| LIFI | Laser-induced Fluorescence Imaging |
| LIFR | Leukemia Inhibitory Factor Receptor |
| LIFS | Laser Induced Fluorescence Spectroscopy |
| LIFT | Laser Induced Forward Transfer |
| LIGA | Lithographie |
| LIGO | Laser-interferometer Gravitational-wave Observatory |
| LIGS | Laser-induced Grating Spectroscopy |
| LII | Liquid Injection Incinerator |
| LILE | Large-ion Lithophile Element |
| LIM | Last Interglacial Maximum (era Of Warm Nonglacial Climate Between PGP And LGM) |
| LIM | Liquid-injection Molding |
| LIMA | Laser-induced Ion-mass Analyzer |
| LIMB | Limestone Injection/multistage Burner |
| LIMS | Laser Ionization Mass Spectrometry |
| LIMS | Limb Infrared Monitor Of The Stratosphere |
| LIMS | Laboratory Information Management System |
| LINE | Long Interspersed Element |
| LINEAR | Lincoln Near Earth Asteroid Research |
| LINF | Laser-induced Native Fluorescence |
| LIOAS | Laser-induced Optoacoustic Spectroscopy |
| LIP | Laser-induced Plasma |
| LIPAS | Laser Induced Photoacoustic Spectroscopy |
| LIPM | Laser Integrating Plate Method |
| LIPOD | Laser Induced Photochemical Oxidative Destruction Process |
| LIPS | Lanthanide Ion Probe Spectroscopy |
| LIPS | Laser-induced Plasma Spectroscopy |
| LIPSS | Laser-induced Periodic Surface Structures |
| LIR | Limiting Infiltration Rate |
| LIRE | Laser Ionization Recombination Emission |
| LIS | Lightning Imaging Sensor |
| LIS | Lanthanide-induced Shift |
| LISA | Laser Interferometer Space Antenna |
| LISA | Library And Information Science Abstracts |
| LISA | Lander For Ion-selective Analysis |
| LISPS | Laser-induced Shock Wave Plasma Spectroscopy |
| LISS | Low Ionic Strength Solution |