| Acronym | Meaning |
| ICTS | Isothermal Capacitance Transient Spectroscopy |
| ICTV | International Committee On The Taxonomy Of Viruses |
| ICU | Intensive Care Unit |
| ICV | Initial Calibration Verification |
| ICVT | Improved Canonical Variational Theory |
| ICWM | Institute Of Chemical Waste Management |
| ICZ | Initial Contact Zone(s) |
| ICZN | International Commission On Zoological Nomenclature |
| ID | Inhibitory Dose |
| ID | Isotope Dilution |
| IDA | International Desalination Association |
| IDA | Isotope Dilution Analysis |
| IDA | Interdigitated Array (microelectrodes) |
| IDA | Iron Deficiency Anemia |
| IDAF | Interacting Distributed Approximating Function (propagator |
| IDCNS | Interdivisional Committee On Nomenclature And Symbols |
| IDD | Insulin-dependent Diabetes |
| IDD | Iodine Deficiency Disorder |
| IDDB | Investigational Drugs Database |
| IDDM | Insulin-dependent Diabetes Mellitus |
| IDE | Insulin Degrading Enzyme |
| IDEA | Integrated Data For Enforcement Analysis |
| IDEAL | Inhalation, Deposition And Exhalation Of Aerosols In/from The Lungs |
| IDEAL | International Digital Electronic Access Library |
| IDF | International Dairy Federation |
| IDF | Insoluble Dietary Fiber |
| IDGE | Isothermal Dendritic Growth Experiment |
| IDI | Ion Dipole Induced (potential Term In Potential Energy Surfaces) See Also LEPS-IDI |
| IDIMS | Interactive Digital Image Manipulation System |
| IDL | Instrument Detection Limit |
| IDLH | Immediately Dangerous To Life Or Health |
| IDMA | Isotopic Dilution And Mass Analysis |
| IDMS | Integrated DWPF Melter System |
| IDMS | Isotope Dilution Mass Spectrometry |
| IDO | Initial Dissolved Oxygen |
| IDOE | International Decade Of Ocean Exploration |
| IDP | Inosine 5'-diphosphate |
| IDP | Interplanetary Dust Particle |
| IDSA | Infectious Diseases Society Of America |
| IDSRS | Ionization-detected Stimulated Raman Spectroscopy |
| IDT | Interdigital Transducer |
| IDTIMS | Isotope Diln. Thermal Ionization Mass Spectrometry |
| IDWSSD | International Drinking Water Supply And Sanitation Decade (of UN |
| IE | Ion Exchange |
| IE | Ionization Energy |
| IEA | Industrial Environmental Association |
| IEA | International Energy Agency |
| IEAES | Ion Excited Auger Electron Spectroscopy |
| IEC | Inertial Electrostatic Confinement |
| IEC | Ion-exchange Chromatography |