| Acronym | Meaning |
 | HI | Hydrogen Index |
| HIAA | Hydroxyindoleacetic Acid |
| HIAF | Heavy Ion Analytical Facility |
| HIBA | 2-hydroxyisobutyric Acid |
| HIBS | Heavy Ion Backscattering Spectrometry |
| HIC | Hydrogen-induced Cracking |
| HIC | Hydrophobic Interaction Chromatography |
| HID | Helium Ionization Detector |
| HID | High Intensity Discharge |
| HID | High Interstitial Defect |
| HIERD | Heavy Ion Elastic Recoil Detection |
| HIERDA | Heavy Ion Elastic Recoil Detection Analysis |
| HIF | Hypoxia Inducible Factor |
| HIFU | High-intensity Focused Ultrasound |
| HIGFET | Heterostructure Insulated Gate Field Effect Transistor |
| HIID | Heavy Ion Induced Desorption |
| HIIS | Heavy Ions In Space |
| HILDA | High-Latitude Exchange/Interior Diffusion-Advection Model |
| HILIC | Hydrophilic Interaction Chromatography |
| HIM | Hydroxy Interlayered Minerals (clay Minerals) |
| HIMAC | Heavy Ion Medical Accelerator In Chiba |
| HIMP | Heavy Ion Microprobe |
| HIMU | High U/Pb Mantle (component) |
| HIP | Hot Isostatic Pressing |
| HIPCO | High-pressure Carbon Monoxide |
| HIPE | High Internal Phase Emulsion |
| HIPRE | High Internal Phase Ratio Emulsion |
| HIPS | High Impact Polystyrene |
| HIRBS | Heavy-ion Rutherford Backscattering Spectrometry |
| HIRDLS | High-Resolution Dynamics Limb Sounder |
| HIRES | High Resolution Echelle Spectrometer |
| HIRIS | High Resolution Imaging Spectrometer |
| HIRLAM | High Resolution Limited Area Model |
| HIS | High Intensity Spectrometer |
| HIT | Hazard Information Transmission |
| HIT | Heparin-induced Thrombocytopenia |
| HIT | Heterojunction With Intrinsic Thin Layer (photovoltaic Cell; Solar Cell) |
| HITC | 1,1',3,3,3',3'-hexamethylindotricarbocyanaine Iodide |
| HITRAN | High-Resolution Transmission Molecular Absorption Database |
| HIV | Human Immunodeficiency Virus |
| HIWIP | Homojunction Interfacial Work-function Internal Photoemission |
| HKED | Hybrid K-edge Densitometry |
| HKF | Helgeson-Kirkham-Flowers (equation Of State) |
| HKS | Hartree-Kohn-Sham (quantum Theory) |
| HKS | Hohenberg-Kohn-Sham (quantum Theory) |
| HL | Mustard-Lewisite Mixture |
| HLA | Human Leukocyte Antigen |
| HLAO | High-lying Antibonding Orbital |
| HLB | Hydrophilic-lipophilic Balance (of Surfactants) |
| HLBR | Required Hydrophilic-lipophilic Balance (of Surfactants In Emulsifiers) |
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