| Acronym | Meaning |
| HERG | Human Ether-a-go-go-related Gene |
| HERL | Health Effects Research Laboratory |
| HERL/MIS | Health Effects Research Laboratory Management Information System |
| HERS | High Energy Range Spectrometer |
| HERV | Human Endogenous Retrovirus |
| HESC | Human Embryonic Stem Cell |
| HESI | Health And Environmental Sciences Institute |
| HESP | Human Exposure To Soil Pollutants |
| HESS | High Energy Stereoscopic System |
| HESSI | High Energy Solar Spectroscopic Imager |
| HETA | Hazard Evaluation Technical Assistance Branch (NIOSH) |
| HETE | High Energy Transient Explorer |
| HETE | Hydroxyeicosatetraenoic Acid |
| HETG | High-energy Transmission Grating |
| HETP | Height Equivalent To A Theoretical Plate |
| HEU | Highly Enriched Uranium |
| HEUR | Hydrophobe Modified Ethoxylated Urethane [polymer] |
| HEV | Hepatitis E Virus |
| HEV | High Endothelial Venule Cell |
| HEV | Hybrid Electric Vehicle |
| HEWL | Hen Egg White Lysozyme |
| HEXS | High-energy X-ray Scattering |
| HF | Heart Failure |
| HF MO LCAO | Hartree-Fock MO LCAO |
| HFA | Humic And Fulvic Acids |
| HFB | Hartree Fock Bogolyubov |
| HFB | Hybrid Fluidized Bed |
| HFB SCF RPA | Hartree Fock Bogolyubov SCF Random Phase Approximation |
| HFBR | High Flux Beam Reactor |
| HFCC | Hyperfine Coupling Constant |
| HFCLM | Hollow Fiber Contained Liquid Membrane |
| HFCVD | Hot Filament Chemical Vapor Deposition |
| HFD | Hartree-Fock-dispersion (type Of Intermol. Potential) |
| HFD-B | Hartree-Fock Dispersion-b (potential |
| HFD-C | Hartree-Fock-dispersion With Repulsive SCF Component (intermol. Potential) |
| HFDA | Hexafluoroisopropylidene-2 |
| HFE | Hot-feed Extrusion |
| HFEGE | Hara Free-electron-gas Exchange (potential) |
| HFET | Highway Fuel Economy Test |
| HFET | Heterostructure Field Effect Transistor |
| HFET | High Field Effect Transistor |
| HFF | Hellmann-Feynman Force Approximation |
| HFFC | Hartree-Fock Frozen Core |
| HFFR | Halogen-free Flame Retardant [thermoplastics] |
| HFFT | Hot Filament Fouling Test |
| HFG | Hartree-Fock-Gopinathan (quantum Theory Or Wave Function) |
| HFI | Hyperfine Interaction |
| HFIR | High Flux Isotope Reactor |
| HFJ | Hartree-Fock-Jucys (in Electron-correlation Corrections Calcn.) |
| HFKS | Hartree-Fock-Kohn-Sham (density-functional Theory) |