| Acronym | Meaning |
| FLO | Face Localized Orbital |
| FLPMA | Federal Land Policy And Management Act |
| FMA | Failure-mode Analysis |
| FMAFSH | FeO-MgO-Al2O3-Fe2O3-SiO2-H2O System |
| FMAP | Fano-Macek Alignment Parameter (in Electron-impact Excitation Of Ions) |
| FMAR | Ferromagnetic Antiresonance |
| FMASH | FeO-MgO-Al2O3-SiO2-H2O System |
| FMAT | Fluorometric Microvolume Assay Technology |
| FMC | Flow Microcalorimetry |
| FMCW | Frequency Modulated Continuous Wave |
| FMD | Foot And Mouth Disease |
| FMDF | Fixed Mirror Distributed Focus (solar Concentrator) |
| FMEA | Failure Mode And Effect Analysis |
| FMECA | Failure-mode Effects And Criticality Analysis |
| FMF | Frozen Molecular Fragment (method In Calcn. Of Intermol. Potentials And Charge Distributions) |
| FMI | Fermilab Main Injector |
| FMIR | Frustrated Multiple Internal Reflection |
| FMIT | Fusion Materials Irradiation Test |
| FML | Flexible Membrane Liner |
| FMM | Fast Multipole Method (algorithm For Coulomb Interactions Among Charge Distributions) |
| FMM | Force Modulation Microscopy |
| FMN | Flavin Mononucleotide |
| FMO | Floating Molecular Orbital |
| FMO | Frontier Molecular Orbital |
| FMO3 | Flavin-containing Monooxygenase-3 |
| FMOS | Flavin-containing Monooxygenases |
| FMR | Ferromagnetic Resonance |
| FMRI | Functional Magnetic Resonance Imaging |
| FMS | Frequency Modulation Spectroscopy |
| FMTBA | Fitted Modified Tight-binding Approxn. |
| FMVCP | Federal Motor Vehicle Control Program |
| FN | Ferrite Number |
| FNA | Fine-needle Aspiration |
| FNAA | Fast Neutron Activation Analysis |
| FNAL | Fermi National Accelerator Laboratory |
| FNMRI | Flow Nuclear Magnetic Resonance Imaging |
| FNO | Frozen Natural Orbital |
| FNOC | Fleet Numerical Oceanography Center (USA Navy) |
| FNSI | Finding Of No Significant Impact |
| FNTS | Fast Neutron Transmission Spectroscopy |
| FO-CPHF | First-order Coupled Perturbed Hartree-Fock Theory |
| FO-ECP | Frozen Orbital-effective Core Potential |
| FO-NACME | First-order Nonadiabatic Coupling Matrix Elements |
| FOA | Frozen Orbital Approximation |
| FOB | Fecal Occult Blood |
| FOB | Functional Observational Battery |
| FOBT | Fecal Occult Blood Test |
| FOCAL | Francais Ocean Et Climat Dans L'Atlantique Equatorial |
| FOCAPD | Foundations Of Computer-aided Process Design |
| FOCI | First-order Configuration Interaction |