| Acronym | Meaning |
 | DMP | Data Management Plan |
| DMS | Data Management System |
| DMS | Device Management System |
| DMSP | Defense Meteorological Satellite Program |
| DMSP SPO | DMSP System Program Office |
| DNA | Defense Nuclear Agency |
| DNFSB | Defense Nuclear Facilities Safety Board |
| DNO | Do Not Operate |
| DNP | Division Of Nuclear Physics |
| DNS | Direct Numerical Simulation |
| DNS | Domain Name Service |
| DNS | Domestic Name System |
| DOA | Department Of Agriculture |
| DOAS | Differential Optical Absorption Spectroscopy |
| DOC | Department Of Commerce |
| DOC | Dissolved Organic Carbon |
| DOD | Digital Omega Dropwindsonde |
| DOD | Department Of Defense |
| DOD | Digital Optical Disk |
| DODCI | Department Of Defense Computer Institute |
| DODP | Department Of Defense Programs |
| DODS | Distributed Ocean Data System |
| DOE | Department Of Energy |
| DOE/HQ | Department Of Energy Headquarters |
| DOE/HQ-EH | DOE Headquarters |
| DOE/ID | DOE Idaho |
| DOE/NV | DOE Nevada Operations Office |
| DOE/RF | DOE Rocky Flats Operations Office |
| DOE/RFO | DOE Rocky Flats Office |
| DOE/RL | DOE Richland Operations |
| DOE/SR | DOE Savannah River |
| DOELAP | DOE Laboratory Accreditation Program |
| DOI | Department Of Interior |
| DOJ | Department Of Justice |
| DOL | Department Of Labor |
| DOMONIC | Johnsten Island Experiment |
| DOMSAT | Domestic Satellite |
| DOOS | DICOMED Online Operating System |
| DOPLID | Doppler Lidar |
| DOPLIGHT | Doppler And Lightning Program |
| DORIS | Determination D'Orbite Et Radiopositionement Integre Par Satellite |
| DORIS | Doppler Orbitography & Radiopositioning Integrated By Satellite |
| DOS | Department Of State |
| DOS | Department Of Space |
| DOS DISK OPERATING SYSTEM | N/A |
| DOSECC | Deep Observation And Sampling Of The Earth's Continental Crust |
| DOT | Department Of Transportation |
| DOW | Defenders Of Wildlife |
| DP | Data Processing |
| DP | Defense Programs |
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