| Acronym | Meaning |
 | APACM | Atmospheric Physical And Chemical Monitor |
| APARE | Asian/Pacific Regional Experiment |
| APAS | Astrophysical |
| APC | Argon Purge Cart |
| APC | Ammonium Perchlorate |
| APCA | Air Pollution Control Association |
| APD | Advanced Planning Division |
| APD | Advance Planning Document |
| APD | Areal Power Density |
| APD | Avalanche Photodiode |
| APDCS | Axial Power Distribution Monitoring System |
| APDF | Accelerator Performance Demonstration Facility |
| APE | Action Plan Element |
| APEN | Air Pollution Emissions Notice |
| APET | Accident Progression Event Tree |
| APEX | Acid Precipitation Experiment |
| APEX | Advance Purchase Excursion |
| APEX | APLE Prototype Experiment |
| APG | Aberdeen Proving Ground |
| APHA | American Public Health Association |
| API | American Petroleum Institute |
| API | Application Program Interface |
| API | Axial Power Indicator |
| API | Absolute Position Indication |
| APIP | Aircraft Produced Ice Particles |
| APJ | The Astrophysical Journal |
| APL | Applied Physics Laboratory |
| APL | Average Power Laser |
| APLE | Average Power Laser Experiment |
| APLJHU | Applied Physics Laboratory John Hopkins University |
| APM | Axial Power Monitor |
| APO | Administrative Policy Office |
| APOL | Analytical Photonics And Opto-Electronics Laboratory |
| APOLLO2 | RTD SRL Code For Operating Limits |
| APPA | American Public Power Association |
| APPLY | Parallel Program Generation |
| APR | Automatic Pressure Relief |
| APR | Aberdeen Pulsed Reactor Facility |
| APRM | Average Power Range Monitor |
| APS | American Physical Society |
| APS | Advanced Power Source |
| APS | Array Processing System |
| APS | Atomic Power Station |
| APS | Auxiliary Power System |
| APS | Autocorrelated Photon Spectroscopy |
| APS | Axial Power Shape |
| APT | Automatic Picture Transmission |
| APT | Alliance For Photonic Technology |
| APT | Accelerator Production Of Tritium |
| APU | Auxiliary Power Unit |
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