| Acronym | Meaning |
 | MBCC | Migratory Bird Conservation Commission (U.S.) |
| MBCS | Multi-Byte Character Set |
| MBE | Member Of The Order Of The British Empire |
| MBIDST | Member Of The British Institute Of Dental And Surgical Technologists |
| MBM | Meat And Bone Meal |
| MBT | Main Battle Tank |
| MBTA | Massachusetts Bay Transportation Authority - Migratory Bird Treaty Act (U.S.) |
| MBTI | Myers-Briggs Type Indicator |
| MC | Macao (FIPS 10-4 Territory Code) -Master Of Ceremonies -Megacoulomb -Military Cross (bravery Award) -Monaco (ISO 3166 Digram) -Mortar Carrier -Eleven Hundred (in Roman Numerals) |
| MC | Millicoulomb |
| MC&G | Mapping |
| MCA | Micro Channel Architecture - MultiChannel Analyzer |
| MCC | Marylebone Cricket Club - Mission Control Centre - Movement Control Centre |
| MCD | Minimal Cerebral Dysfunction |
| MCDL | Model Composition Definition Language |
| MCI | Microwave Communications |
| MCIS | Mellon Collie And The Infinite Sadness |
| MCM | Mine Counter-Measures |
| MCMV | Mine Counter-Measure Vessel |
| MCO | Monaco (ISO 3166 Trigram) -Movement Control Officer -Major Combat Operation |
| MCP | Maintenance Collection Point - Male Chauvinist Pig |
| MCR | My Chemical Romance |
| MCSF | Marine Corps Security Forces |
| MCT | Movement Control Team |
| MCTIS | Mounted Co-operative Target Identification System |
| MD | Fifteen Hundred (in Roman Numerals) - Maryland (postal Symbol) -Medicinae Doctor (Doctor Of Medicine/Medical Doctor) - Mentioned In Dispatches (military) -Moldova (FIPS 10-4 Country Code; ISO 3166 Digram) |
| MD | Mendelevium |
| MDA | Main Defensive Action/Area -Moldova (ISO 3166 Trigram) - Muscular Dystrophy Association |
| MDF | Main Distribution Frame - Medium-Density Fibreboard |
| MDG | Madagascar (ISO 3166 Trigram) -UN Millennium Development Goal |
| MDL | Moldovan Leu (ISO 4217 Currency Code) |
| MDM | Michigan Dartmouth MIT Telescope Consortium |
| MDMA | MethyleneDioxy-MethylAmphetamine (also Known As Ecstasy) |
| MDO | Membership Driven Organisation |
| MDP | Markov Decision Process |
| MDT | Mountain Daylight Saving Time (UTC-6 Hours) |
| MDV | Maldives (ISO 3166 Trigram) |
| MDW | Chicago Midway International Airport In Chicago |
| ME | Maine (postal Symbol) -Mechanical Engineer[ing] - Medical Examiner - Middle East -Middle East Airlines (IATA Code) -Memory Effect - Myalgic Encephalomyelitis |
| ME | Messerschmitt |
| MEA | Maine Educational Assessment - Middle East Airlines - Millennium Ecosystem Assessment - Minimum Enroute Altitude - Mono-ethanol Amine - Multilateral Environmental Agreement |
| MEC | Maine Central Railroad (AAR Reporting Mark) - Manta |
| MECC | Minnesota Educational Computing Consortium (later Corporation |
| MECO | Main Engine Cutoff (NASA Code For Point In Space Shuttle Assent When Three Main Engines Are Shut Down Prior To External Tank (ET) Separation) |
| MEDEVAC | Medical Evacuation |
| MEDS | Mission Essential Data Set |
| MEF | U.S. Marine Expeditionary Force - Minimum Essential Facility - Mission Essential Force |
| MEG | MagnetoEncephaloGraphy |
| MEI | Matsushita Electric Industrial Co. |
| MEK | Magyar Elektronikus Konyvtar - Message Encryption Key - Methyl Ethyl Ketone -Mujahideen Al-Khalq |
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