| Acronym | Meaning |
 | DCOP | Desktop Communication Protocol |
| DCSOPS | Deputy Chief Of Staff For Operations And Plans |
| DCW | Digital Chart Of The World |
| DCYSC | Discovery Channel Young Scientist Challenge |
| DD | Many |
| DDA | Digital Differential Analyzer - Deputy District Attorney |
| DDD | Data Display Debugger - Digital Digital Digital (CD Mastering) |
| DDL | Digital Data Link |
| DDN | U.S. Defense Data Network |
| DDOS | Distributed Denial Of Service |
| DDR | Dance Dance Revolution - Deutsche Demokratische Republik (German |
| DDR&E | (U.S.) Director Of Defense Research And Engineering (1958?1978) |
| DDS | Doctor Of Dental Surgery |
| DDT | Dichloro-Diphenyl-Trichloroethane (insecticide) - Dynamic Debugging Tool (computing) |
| DE | Delaware (postal Symbol) - Germany (ISO 3166 Digram) |
| DE | German Language (ISO 639-1 Code) |
| DEA | Drug Enforcement Agency |
| DEC | Department Of Environmental Conservation - Digital Equipment Corporation - Disasters Emergency Committee |
| DECA | (U.S.) Defense Commissary Agency |
| DECSIM | Model DEComposition And SIMulation Algorithm - Directed Energy Combat SIMulation |
| DECT | Digital European Cordless Telephone |
| DEFCON | Defence Readiness Condition |
| DEFRA | (UK) Department For Environment |
| DEM | Data Exchange Mechanism - Digital Elevation Model |
| DEPSECDEF | (U.S.) Deputy Secretary Of Defense |
| DERA | British Defence Evaluation And Research Agency (1995?2001) |
| DES | Deep Ecliptic Survey |
| DEU | German Language (ISO 639-2 Code) |
| DEU | Germany (ISO 3166 Trigram) |
| DF | Direct Fire - Direction Finding |
| DFAD | Digital Feature Analysis Data (dee-fad) |
| DFAS | (U.S.) Defense Finance And Accounting Service |
| DFB | Deutscher Fu Ball-Bund (German For German Football Association) |
| DFCB | Data Format Control Book |
| DFID | UK Department For International Development |
| DFM | Dynamic Flowgraph Methodology |
| DFSP | Dermatofibrosarcoma Protuberans |
| DG | Dei Gratia (Latin |
| DGA | Direction G?n?rale Des Arm?es (French Armed Forces General Directorate) |
| DGD&D | UK Directorate General Of Development And Doctrine |
| DGPS | Differential GPS |
| DGZ | Desired Ground Zero |
| DH | Dear Husband (increasingly Prevalent On Social Mailing Lists |
| DHA | DocosaHexaenoic Acid |
| DHHS | (U.S.) Department Of Health And Human Services |
| DHL | Dalsey |
| DHRA | (U.S.) DoD Human Resources Activity |
| DHS | U.S. Department Of Homeland Security |
| DHSS | UK Department Of Health And Social Security |
| DHY | Dahomey (ISO 3166 Trigram; Became BEN In 1977) |
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