| Acronym | Meaning |
 | CO | Many |
| COA | Concept Of Analysis - Course Of Action (military) |
| COB | Close Of Business [day] |
| COBOL | COmmon Business-Oriented Language |
| COCOM | Combatant Command (military) |
| COD | Cash On Delivery -Democratic Republic Of The Congo (ISO 3166 Trigram) |
| CODEC | Coder-Decoder / Compressor-Decompressor / Compression-Decompression Algorithm |
| COE | Cab Over Engine (see Truck) - Common Operating Environment (military) |
| COEA | Cost Operational Effectiveness Analysis (military) |
| COEIA | Combined Operational Effectiveness And Investment Appraisal (military) |
| COFT | Conduct Of Fire Trainer (military) |
| COG | Centre Of Gravity - Current Operations Group (military) -Republic Of The Congo (ISO 3166 Trigram) |
| COGENT | Cognitive Objects Within A Graphical EnviroNmenT |
| COIN | Counter-Insurgency (military) |
| COK | Cook Islands (ISO 3166 Trigram) |
| COL | Colombia (ISO 3166 Trigram) |
| COLA | Comp.os.linux.announce - Cost Of Living Adjustment |
| COLT | Combat Observation And Lasing Team (military) |
| COM | Comoros (ISO 3166 Trigram) -Component Object Model |
| COMECON | Council For Mutual Economic Assistance (economic Counterpart Of The Warsaw Pact |
| COMMZ | Communications Zone (military) |
| COMSEC | Communications Security (military) |
| CONAD | U.S. Continental Air Defense Command |
| CONCACAF | Confederation Of North |
| CONMEBOL | Confederaci›n Sudamericana De Fœtbol (Spanish |
| CONOPS | Concept Of Operations (military) |
| CONUS | Continental United States |
| COO | Chief Operating Officer |
| COP | Colombian Peso (ISO 4217 Currency Code) -Common Operating/Operational Picture |
| COPE | U.K. Committee On Publication Ethics |
| COPUS | U.K. Committee On The Public Understanding Of Science |
| COR | Cornish Language (ISO 639-2 Code) |
| CORBA | Common Object Request Broker Architecture |
| CORD | Common Operational Requirements Document |
| CORG | (U.S.) Combat Operations Research Group |
| COROT | COnvection |
| COS | Cooper Ornithological Society |
| COS | Corsican Language (ISO 639-2 Code) - Cosine |
| COSCOM | Corps Support Command (military) |
| COSER | COoperative SERvice |
| COTS | Commercial Off The Shelf |
| COY | Company (military Unit) |
| CP | Canadian Pacific - Check Point - Command Post |
| CPA | Certified Public Accountant |
| CPAC | Canadian Parliamentary Affairs Channel - Conservative Political Action Conference (see-pack) |
| CPD | Capabilities Production Document |
| CPE | Certificate Of Proficiency In English |
| CPF | Calibration Parameter File - Canadian Patrol Frigate |
| CPG | Clinical Practice Guideline |
| CPON | Certified Pediatric Oncology Nurse |
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