| Acronym | Meaning |
 | MOD | Mission Objectives Document |
| MOD | Mission Operations Director |
| MOD | Modification |
| MOD | Modify |
| MODARI- | Methods Of Defeating Advanced Radar Threats |
| MODEM | Modulator-Demodulator |
| MODS | Modifications |
| MOF | Manned Orbital Flight |
| MOL | Molecular |
| MOM | Moment |
| MON | Monitor |
| MOP | Mission Operations Plan |
| MOPI | Max Rate Output Initiator |
| MOPR | Mission Operations Planning Review |
| MOPR | Mission Operations Planning Room |
| MOPS | Military Operations Phone System |
| MOPS | Mission Operations Planning System |
| MOR | Manufacturing Operation Record |
| MORD | Medical Operations Requirements Document |
| MORD | Mission Operations Requirements Document |
| MORT | Management Oversight And Risk Tree |
| MOS | Metal Oxide On A Substrate |
| MOS | Metal Oxide Semiconductor |
| MOSPO | Mobile Satellite Photometric Observatory |
| MOT | Motor |
| MOU | Memorandum Of Understanding |
| MOV | Main Oxidizer Valve |
| MOV | Main Oxidizer Valve |
| MOW | Mission Operations Wing |
| MP | Management Package |
| MP | Mass Properties |
| MP | Measuring Point |
| MP | Medium Pressure |
| MP | Melting Point |
| MP | Meteorology Panel |
| MP | Mission Planner |
| MP | Mod Package |
| MP&C | Maintenance Planning And Control |
| MPAD | Mission Planning And Analysis Division (JSC) |
| MPB | Maintenance Parts Breakdown |
| MPC | Manual Pointing Controller |
| MPC | Memory Protection Check |
| MPC | Meteorological Prediction Center |
| MPC | Mid Power Controller |
| MPC | Midbody Pyro Controller |
| MPCA | Mid Power Controller Assembly |
| MPD | Main Dc Power Distributor Assembly |
| MPD | Maximum Permissible Dose |
| MPESS | Mission Peculiar Experiment Support Structure |
| MPG | Multiple Point Ground |
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