| Acronym | Meaning |
 | MFMR | Multifrequency Microwave Radiometer |
| MFO | Major Function Overlay |
| MFR | Manipulator Foot Restraint |
| MFR | Maximum Flight Rate |
| MFR | Multifunctional Receiver |
| MFR | Multifunctional Review |
| MFT | Mean Flight Time |
| MFTAD | Master Flight Test Assignment Document (JSC) |
| MFV | Main Fuel Valve |
| MFV | Main Fuel Valve |
| MG | Magnesium |
| MG | Middle Gimbal (YAW) |
| MG | Milligram |
| MG | Mobile Generator |
| MGA | Middle Gimbal Angle |
| MGC | Manual Gain Control |
| MGE | Maintenance Ground Equipment |
| MGMT | Management |
| MGR | Manager |
| MGSE | Mechanical Ground Support Equipment |
| MGT | Major Ground Test |
| MGVT | Mated Ground Vibration Test |
| MHA | Multiple Headset Adapter |
| MHC | Manipulator Hand Controller |
| MHD | Multihead Disc |
| MHE | Material Handling Equipment |
| MHF | Medium High Frequency |
| MHSC | Manipulator Handset Controller |
| MHW | Multihundred Watt |
| MHZ | Megahertz (Megacycles Per Second) |
| MI | Management Information |
| MI | Mechanical Joint |
| MI | Mile |
| MIA | Multiflex Interface Adapter |
| MIA | Multiplexer Interface Adapter |
| MIA | Multiplexer Interface Adapter |
| MIB | Master Interconnect Board |
| MIC | Management Information Center |
| MICIS | Material Information Control And Information System |
| MID | Midbody |
| MIL | GSFC Spaceflight Tracking And Data Network Station |
| MIL | Military |
| MILA | Merritt Island Launch Area |
| MILLS | Modular Integrated Utility Systems |
| MILS | Missile Impact Location System |
| MILSTRIP | Military Standard Requisition And Issue Procedure |
| MIMOSA | Mission Modes And Space Analysis |
| MIMS | Medical Information Management System |
| MIN | Minimum |
| MIN | Minute |
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