| Acronym | Meaning |
 | MEIG | Main Engine Ignition |
| MEIU | Main Engine Interface Unit |
| MEL | Master EquipmentList |
| MEL | Minimum Equipment List |
| MELI | Master Equipment List Index |
| MELI | Minimum Equipment List Index |
| MEM | Meteoroid Exposure Module |
| MEM | Module Exchange Mechanism |
| MEOP | Maximum Expected Operating Pressure |
| MEP | Main Engine Propellant |
| MEP | Main Entry Point |
| MEP | Management Engineering Program |
| MEP | Mean Effective Pressure |
| MEP | Minimum Entry Point |
| MEP | Minimum Entry Point |
| MER | Meridian |
| MER | Mission Evaluation Room |
| MERL | Materials Engineering Research Laboratory |
| MERL | Materials Equipment Requirement List |
| MERSAT | Meteorology And Earth Observation Satellite |
| MERU | Milliearth Rate Unit |
| MES | Main Engine Start |
| MES | Mated Events Simulator |
| MES | Mated Elements Simulator |
| MES | Mission Events Sequence |
| MESC | Master Events Sequencer Controller |
| MET | Master Events Timer |
| MET | Meteorological |
| MET | Mission Elapsed Time |
| MET | Mission Elapsed Time |
| MET | Mission Events Timer |
| METRO | Meteorology |
| METVC | Main Engine Thrust Vector |
| MEWG | Maintenance Engineering Working Group |
| MF | Major Function |
| MF | Master Frame |
| MF | Mate And Ferry |
| MF | Medium Frequency (300 To 3000 KHz) |
| MF | Middeck Forward |
| MF | Midfuselage |
| MFA | Manned Flight Awareness |
| MFBP | Manufacturing Flow And Building Plan |
| MFC | Multiple Flight Computer |
| MFC | Multiple Flight Controller |
| MFD | Main Feed |
| MFD | Malfunction Detection |
| MFE | Mid Frequency Executive |
| MFF | MDM Flight Forward |
| MFG | Major Functional Group |
| MFG | Manufacturing |
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