| Acronym | Meaning |
 | MDM | Multiplexer/Demultiplexer |
| MDM | Multiplexer/demultiplexer |
| MDR | MaintenanceDemandRate |
| MDR | Major Design Review |
| MDR | Minor Discrepancy Repair |
| MDR | Missing Data Report |
| MDR | Mission Data Reduction |
| MDR | Monthly Director's Review |
| MDRD | Mission Data Requirements Document |
| MDRS | Manufacturing Data Retrieval System |
| MDRS | Mission Data Retrieval System |
| MDS | Malfunction Detection System |
| MDS | Management Data System |
| MDS | Master Development Schedule |
| MDS | Minimum Discernible Signal |
| MDS | Minimum Discernible System |
| MDS | Mission Development Simulator |
| MDT | MaintenanceDemandTime |
| MDT | Mean Detonating Time |
| MDT | Mean Down Time |
| MDT | Measurement Descriptor Table |
| MDT | Mountain Daylight Time |
| MDTSCO | McDonnell Douglas Technical Services Company |
| ME | Main Engine |
| ME | Management Engineering |
| ME | Miscellaneous Equipment |
| MEA | Main Electronics Assembly |
| MEA | Maintenance Engineering Analysis |
| MEA | Material Experiment Assembly |
| MEAR | Maintenance Engineering Analysis Request |
| MEAS | Measuring |
| MEB | Main Electronics Box |
| MEBO | Main Engine Burnout |
| MEC | Main Engine Controller |
| MEC | Master Event Controller |
| MEC | Master Events Controller |
| MEC | Mission Events Controller |
| MECA | Main Engine Controller Assembly |
| MECF | Main Engine Computational Facilities |
| MECH | Mechanical |
| MECO | Main Engine Cutoff |
| MECO | Main Engine Cutoff |
| MECR | Maintenance Engineering Change Request |
| MED | Manual Entry Device |
| MED | Medical |
| MED | Medium |
| MEDICS | Medical Information Computer System |
| MEE | Mission Essential Equipment |
| MEG | Megohm |
| MEI | Master Inspection Item |
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