| Acronym | Meaning |
 | CBP | Connector Bracket Power |
| CBRF3 | Bromotrifluoromethane (Fire-Extinguishing Material) |
| CBS | Connector Bracket Signal |
| CBSA | Cargo Bay Stowage Assembly |
| CBV | Cabin Bleed Valve |
| CBW | Constant Bandwidth |
| CBX | C-Band Transponder |
| CC | Carbon-Carbon |
| CC | Channel Controller |
| CC | Chief Counsel (KSC Directorate) |
| CC | Communications Control |
| CC | Cost Center |
| CC | Crew Compartment |
| CC | Crew(s) Certified |
| CCA | Communications Carrier Assembly |
| CCA | Communications Carrier Assembly |
| CCA | Contract Change Authorization |
| CCA | Contract Change Authorization |
| CCA | Coolant Control Assembly |
| CCAFS | Cape Canaveral Air Force Station |
| CCAFS | Cape Canaveral Air Force Station |
| CCATS | Command |
| CCB | Change Control Board |
| CCB | Configuration Change Board |
| CCB | Configuration Control Board |
| CCBD | Configuration Control Board Directive |
| CCC | Central Computer Complex |
| CCC | Communication(s) Control Console |
| CCC | Complex Control Center |
| CCC | Contaminant Control Cartridge |
| CCC | Controller Checkout Console |
| CCD | Charge Coupled Device |
| CCD | Checkout Command Decoder |
| CCD | Constants Change Display |
| CCDR | Contractor Critical Design Review |
| CCE | Computer Command Engineer |
| CCF | Converter Compressor Facility |
| CCFF | Cape Canaveral Forecast Facility |
| CCIM | Command Computer Input Multiplexer |
| CCIR | International Radio Consultative Committee |
| CCL | Closed Circuit Loop |
| CCL | Commonality Candidate List |
| CCL | Configuration Control Logic |
| CCM | Controlled Carrier Modulation |
| CCM | Crew/Cargo Module |
| CCM | E Contract Change Mass Estimate |
| CCMS | Checkout |
| CCMS | Checkout |
| CCMS | Command Control And Monitor System |
| CCN | Contract Change Negotiation |
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