| Acronym | Meaning |
 | ISCM | JSC Manual |
| ISI | Initial Systems Installation |
| ISI | Instrumentation Support Instruction |
| ISIL | Interim Support Items List |
| ISL | Inertial Systems Laboratory |
| ISL/LAR | Integrated Logistics System And Logistics Assessment |
| ISL/LAR | Review |
| ISLM | Integration Shop/Lab Manager |
| ISO | International Standardization Organizations |
| ISOL | Isolate |
| ISP | Initial Specific Impulse |
| ISP | Instrumentation Support Plan |
| ISP | Integrated Support Plan |
| ISPG | Institutional Support Planning GrouP |
| ISPM | International Solar Polar Mission |
| ISR | Initial System Release |
| ISS | Inertial Subsystem |
| ISS | Inhibit/Override Summary Snapshot Display |
| ISS | Installation Support Services |
| ISS | Instruction Summary Sheet |
| ISS | Integrated System Schematic |
| ISSL | Initial Spares Support List |
| ISSUING | AgeIssuing Agency |
| ISTA | Intertank Structural Test Assembly |
| ISTB | Integrated Subsystem Test Bed |
| ISTF | Integrated System Test Flow |
| IT | Identification Transponder |
| IT | Installation Test |
| ITA | Integrated Test Area |
| ITA | Integrated Test Article |
| ITAP | Integrated Technical Assessment Panel |
| ITC | Igloo Thermal Control |
| ITE | Instrumentation Test Equipment |
| ITE | Integration Test Equipment |
| ITE | Intersite Transportation Equipment |
| ITERATIVE | GIterative Guidance Mode |
| ITI | Inspection And Test Instruction |
| ITL | Integrate |
| ITMG | Integrated Thermal/Micrometeoroid Garment |
| ITO | Integration And Test Order |
| ITRDS | Integrated Test Requirements Documents |
| ITS | Instrumentation Telemetry Station |
| ITS | Interim Teleprinter System |
| IU | Instrument Unit |
| IU | Interface Unit |
| IU | Interface Unit |
| IUA | Inertial Unit Assembly |
| IUA | Interface Unit AdaPter |
| IUE | Interface Unit Error Count Table |
| IUS | Inertial Upper Stage |
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