| Acronym | Meaning |
 | IDWA | Interdivisional Work Authorization |
| IE | Industrial Engineering |
| IEA | Integrated Electronic Assembly |
| IEA | Integrated Electronic Assembly |
| IECS | Igloo Environment Control Subsystem |
| IED | Interacting Equipment Documents |
| IEF | Isoelectric Focusing |
| IEP | Instantaneous Effective Photo Cathodes |
| IF | Integration Facility |
| IFA | In-FlightAnalyses |
| IFASC | Integrated Functions Assessment Steering Committ |
| IFB | Invitation For Bid |
| IFM | In-FlightMaintenance |
| IFO | Information Systems Office |
| IFOT | In-Flight Operations And Training |
| IFR | Instrument Flight Rules |
| IFRU | In-Flight Replacement Unit |
| IFT | In-Flight Test |
| IFTM | In-Flight Test Maintenance |
| IFTS | In-Flight Test System |
| IFU | InterfaceUnit |
| IG | Igloo |
| IGA | Inner Gimbal Angle |
| IGAX | Inner Gimbal Axis |
| IGDS | Iodine Generating And Dispensing SYstem |
| IGM | Interactive Guidance Mode |
| IGN | Ignition |
| IGOR | Intercept Ground OPtical Recorder |
| IGS | Inertial Guidance System |
| IGSE | In-Space Ground SUPPort Equipment |
| IGV | Inlet GUide Valve/Vanes |
| IH/SR | Integration Hardware And Software Review |
| IHP | Indicated Horsepower |
| IHTV | Interim Hypersonics Test Vehicle |
| IHX | Interloop Heat Exchanger |
| IIS | InsPection Item Sheet |
| IIS | Joint Integrated Simulation |
| IITCS | Igloo Internal Thermal Control Section |
| ILA | Instrument Landing Approach |
| ILC | Initial Launch Capability |
| ILC | International Latex Corporation |
| ILLUM | Illuminate |
| ILP | IntegratedLogistics Panel |
| ILS | InstrumentLanding System |
| ILS | IntegratedLogistics Support |
| ILS | IntegratedLogistics System |
| ILS/LAR | IntegratedLogistics System And Logistics Assess |
| ILS/LAR | Review |
| ILSSE | Integrated Life Science Shuttle Experiments |
| IMBLMS | Integrated Medical Behavioral Laboratory Measuremen |
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