| Acronym | Meaning |
 | FPS | Flight Per Second |
| FPS | Forward Power Supply |
| FPS | Frames Per Second |
| FPS2 | Feet Per Second Squared |
| FPU | Floating Point Unit |
| FPV | Flow Proportioning Valve |
| FQ | Flight Qualification |
| FQI | Flight Qualification Instrumentation |
| FQR | Flight Qualification Recorder |
| FQR | Flight Qualification Review |
| FQT | Formal Qualification Test |
| FR | Firing Room |
| FR | Flight Rule |
| FR | Frame |
| FRAGNET | Fragmented Network |
| FRB | Failure Review Board |
| FRC | Flight Research Center |
| FRCI | Fibrous Refractory Composite Insulation |
| FRCS | Forward Reaction Control System |
| FRCS | Forward Reaction Control System (Subsystem) |
| FRD | Flight Requirements Document |
| FRE | Flight Related Element |
| FRE | Format Request Element |
| FREO | DIV FrequencY Divider |
| FREQ | Frequency |
| FREQ | CONV Frequency Converter |
| FRF | Flight Readiness Firing |
| FRFT | Flight Readiness Firing Test |
| FRJD | Forward Reaction Jet Driver |
| FRL | Frame Reference Line |
| FRL | Fuselage Reference Line |
| FRMT | Format |
| FRP | Fuselage Reference Plane |
| FRR | Flight Readiness Review |
| FRRID | Flight Readiness Review Item DescriPtion |
| FRRID | Flight Readiness Review Item DisPosition |
| FRSI | Felt Reusable Surface Insulation |
| FRSI | Flexible Reusable Surface Insulation |
| FRT | Flight Readiness Test |
| FRT | Flight Readiness Training |
| FRT | FrequencY ResponseTest |
| FRZR | Freezer |
| FS | Fail To Sync |
| FS | Fail-Safe |
| FS | Fault Summary |
| FS | Federal Specification |
| FS | Fire Suppression |
| FS | Flight System |
| FS | Freon Servicer |
| FS | Full Scale |
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