| Acronym | Meaning |
 | FBS | Firefighters Breathing System |
| FBV | Field Base Visit |
| FBV | Fuel Bleed Valve |
| FC | Fit Check |
| FC | Flight Computer |
| FC | Flight Control |
| FC | Flight Control |
| FC | Flight Critical |
| FC | Flight Critical |
| FC | Fuel Cell |
| FC | Fuel Cell |
| FCA | Fluids Control Assembly |
| FCA | Forward Controller Assembly |
| FCA | Frequency Control Analysis |
| FCA | Functional ComPatibility Analysis |
| FCA | Functional Configuration Audit |
| FCAF | Flight Crew Accommodations Facility |
| FCAP | Flight Control Applications Program |
| FCC | Federal Communications Commission |
| FCC | Flat Conductor Cable |
| FCC | Flight Control Computer |
| FCC | Flight Crew Compartment |
| FCCP | Firm Contract Cost ProPosal |
| FCD | Flight Control Division (JSC) |
| FCDB | Flight Control Data Bus |
| FCE | Flight Control Equipment |
| FCE | Flight Crew Equipment |
| FCEF | Flight Crew Equipment Facility |
| FCEI | Facility Contractor End Item |
| FCF | First Captive Flight |
| FCF | Flight Critical Forward |
| FCF | Functional Check Flight |
| FCFM | Flight Combustion Facility Monitor |
| FCH | Flight Controllers Handbook |
| FCH | L Flight Control Hydraulics Laboratory |
| FCI | Flight Control Indicator |
| FCI | Functional Configuration Identification |
| FCIM | Flight Control Interface Module |
| FCIP | Flight Cargo Implementation Plan |
| FCIT | First Computer Interface Tester |
| FCL | Freon Coolant Line |
| FCL | Freon Coolant Loop |
| FCL | Freon Coolant Loop |
| FCMU | Foot Controlled Maneuvering Unit |
| FCN | Function |
| FCO | Final Checkout |
| FCO | Functional Checkout |
| FCOH | Flight Controllers Operational Handbook |
| FCOS | Flight Computer Operating System |
| FCOS | Flight Computer Operating System (Orbiter) |
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