| Acronym | Meaning |
 | COMPL | Completed |
| COMPOOL | Common Data Pool |
| COMPR | Compress |
| COMPT | COmPartment |
| COMR&DSAT | Communication Research And Development Satellite |
| COMSAT | Communications Satellite |
| COMSEC | Communications Security |
| CON | Contact |
| CONCN | Concentration |
| COND | Condition |
| COND | Condenser |
| CONDR | Conditioner |
| CONF | Conference |
| CONFIG | Configuration |
| CONN | Connect |
| CONS | Console |
| CONSTR | Construct |
| CONT | Continue |
| CONT | Container |
| CONT | Contingency |
| CONTAM | Contaminate |
| CONTIG | Contiguous |
| CONTR | Control |
| CONUS | Continental United States |
| CONV | Converter |
| COOP | Cooperative |
| COORD | Coordinate |
| COP | Contingency Operations Plan |
| COQ | Certificate Of Qualification |
| COR | Contracting Officer Representative |
| CORE | Common Operational Research Equipment |
| COS | Carry-on Oxygen System |
| COS | Console Operating System |
| COS | Cosine |
| COSATI | Committee On Scientific And Technical Information |
| COSI | Closeout System Installation |
| COSTA | Cost Accounting (Code) |
| COV | CutoffValve |
| CP | CandlePower |
| CP | Cargo Program Office (KSC) |
| CP | Cargo Projects Office (KSC) |
| CP | Center Of Pressure |
| CP | Chemically Pure |
| CP | Circular Pitch |
| CP | Cold Plate |
| CP | Console Processor |
| CP | ControlPanel |
| CP | ControlPoint |
| CP-DPO | Deployable Payloads Projects Office (KSC) |
| CP-FEO | Cargo Facilities And GSE Projects Office (KSC) |
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