| Acronym | Meaning |
 | SCNP | Preliminary Specification Change Notice |
| SCNR | Scanner |
| SCO | Start Checkout |
| SCO | Stiper Critical Oxygen |
| SCO | Subcarrier Oscillator |
| SCO | Switch Closure Out |
| SCOE | Special Checkout Equipment |
| SCOS | Subsystem Computer Operating System |
| SCP | Scanner Control Power |
| SCP | Specific Candle Power |
| SCR | Schedule Change Request |
| SCR | Sneak Circuit Report |
| SCR | Software Change Request |
| SCR | Stripchart Recorders |
| SCRG | SYstem Change Review Group (MSFC) |
| SCRL | Station Configuration Requirement List |
| SCRS | Serialized Control And Reporting System |
| SCRS | Stripchart Recording System |
| SCRSY | Serialized Control And Record SYstem |
| SCS | Secondary Coolant System |
| SCS | Spacecraft Control System |
| SCS | Stabilization And Control SYstem (Subsystem) |
| SCSG | Strain Gauge Signal Conditioner |
| SCT | Scanning Telescope |
| SCU | Secondary Control Unit |
| SCU | Sequence Control Unit |
| SCU | Service And Cooling Umbilical |
| SCU | Signal Conditioner Unit |
| SCU | Signal Conditioning Unit |
| SCU | Signal Control Unit |
| SD | Scaling And DisPlay |
| SD | Smoke Detector |
| SD | Space Division (AFSC) |
| SD | Space Division (Rockwell) |
| SD | Spare DisPosition |
| SD | Specification Document |
| SD | LSoftware Development Laboratory |
| SD | LStandard Distribution List |
| SD/FS | Smoke Detector/Fire SuPpression |
| SD/FS | SuPPlier Documentation |
| SD/YVV | SD/Launch Base Div['si'on |
| SDA | Shaft Drive Axis |
| SDAF | Solid Rocket Booster Disassembly Facility |
| SDAF | Source Data Automatic)n |
| SDB | Shallow Draft Barge |
| SDC | Shallow Draft Board |
| SDC | Software DeveloPment COmPuter |
| SDC | Spares DisPosition Code |
| SDCL | SuPPlier Documentation Checklist |
| SDCP | Summary DeveloPment Cost Plan |
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