| Acronym | Meaning |
 | SB | Speed Brake |
| SB | Synchronization Base |
| SB | Synchronization Bit |
| SBA | Seat Back Assembly |
| SBA | Small Business Administration |
| SBA | Structure Borne Acoustic |
| SBAS | S-Band AntennaSwitch |
| SBC | SpeedBrakeCommand |
| SBCR | Stock Balance And Consumption Report |
| SBD | Schematic Block Diagram |
| SBE | Sub-Bit Encoder |
| SBHC | Speed Brake Hand Controller |
| SBP | San Luis Obispo (TACAN Station) |
| SBP | Sonic Boom Panel |
| SBS | Satellite Business System |
| SBTC | Speed Brake/Thrust Controller |
| SBTC | Speed Brake/thrust Controller |
| SBX | S-Band Transponder |
| SC | Scale |
| SC | Service Charge |
| SC | Signal Conditioner (S/C Preferred) |
| SC | Statement Of Capability |
| SC | Statement Of Compatibility |
| SC | Support Contractor |
| SC | Surface Command |
| SCA | Schedule Change Authorization |
| SCA | Sequence Control Assembly |
| SCA | Sequence Control Assembly |
| SCA | Shuttle Carrier Aircraft |
| SCA | Shuttle Carrier Aircraft |
| SCA | Simulation Control Area |
| SCA | Sneak Circuit Analysis |
| SCAMA | Station Conferencing And Monitoring Arrangement |
| SCAN | Antenna Scan |
| SCAN | Selected Current Aerospace Notices |
| SCAPE | Self-contained Atmosphere Protective Ensemble |
| SCAPE | Self-Contained Atmospheric Protective Ensembly |
| SCARS | Sneak Circuit Analysis Report Summary |
| SCAS | Subsystem COMPuter Application Software |
| SCAT | Space CommunicationandTracking |
| SCATS | Storage |
| SCB | Schedule Change Board |
| SCB | Selection Control Board |
| SCB | Selector Control Box |
| SCB | Simulation Control And Training SYstem |
| SCB | Software Control Board |
| SCB | Specification Control Board |
| SCBD | Seller's Approved Configuration Ase Ine |
| SCC | Safety Control Center |
| SCC | Simulation Control Center |
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