| Acronym | Meaning |
 | PROG | Progress |
| PROJ | Project |
| PROM | Progammable Read-only Memory |
| PROM | Programmable Read-Only Memory |
| PROP | Propellant |
| PROP | Proportioning |
| PROP | Propulsion |
| PROP | Propulsion Engineer |
| PROPLT | Propellant |
| PROX | Proximity |
| PRP | Personnel Reliability Program |
| PRPS | Programming Requirements Process Specification |
| PRR | Parts Replacement Request |
| PRR | Preliminary Requirements Review |
| PRR | Program Requirements Review |
| PRR | Pulse Repetition Rate |
| PRS | Payload Retention Subsystem |
| PRS | Personnel Rescue Service |
| PRS | Personnel Rescue System |
| PRS | Power Reactant System (Subsystem) |
| PRS | Precision Ranging System |
| PRS | PrimaryRecoverySite |
| PRS | Primary Rescue Site |
| PRS | Provisioning Requirements Statement |
| PRSD | Power Reactant Storage And Distribution |
| PRSD | Power Reactant Storage And Distribution |
| PRSD | Power Reactant Supply And Distribution |
| PRSDS | Power Reactant Storage And Distribution System |
| PRSS | Problem Report Squawk Sheet |
| PRT | PulseRepetitionTime |
| PRTLS | Powered Return To Launch Site |
| PRV | Pressure Reduction Valve |
| PS | Parachute Subsystem |
| PS | Payload Specialist |
| PS | Payload Station |
| PS | Payload Support |
| PS | Power Supply |
| PS | Pressure Switch |
| PS | Prime Select |
| PS/FC | Power Supply/Fuel Cell |
| PSA | Payload Service Area |
| PSA | Payload Support Avionics |
| PSA | PowerServoAssembly |
| PSA | Power Servo Am Pl If Ier |
| PSA | Pre/Post Sleep Activity |
| PSA | Preferred StorageArea |
| PSA | Pressure Switch Assembly |
| PSA | Provisions Stowage Assembly |
| PSAC | Presidential Scientific Advisory Committee |
| PSC | Parallel Switch Control |
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