| Acronym | Meaning |
 | OMDR | Operations And Maintenance Data Record |
| OMDRI | Operations And Maintainability Data Record |
| OME | Orbital Main Engine |
| OMET | Orbiter Mission Elapsed Time |
| OMEWG | Orbiter Maintenance Engineering Working Group |
| OMI | Operations And Maintenance Instruction |
| OMIS | Operational Management Information System |
| OMISS | Operation And Maintenance Instruction Summary Sheet(s) |
| OML | Orbiter Mold Line |
| OML | Outer Mold Line |
| OML | Outside Mold Line |
| OMMH | Orbiter Maintenance Man-Hours |
| OMNI | Omnidirectional |
| OMNI | Omni-Range |
| OMP | Operations And Maintenance Plan |
| OMPR | Operational Maintainability Problem Reporting |
| OMPT | Observed Mass Point Trajectory |
| OMR | Operations And Maintenance Requirements |
| OMR | Operations Management Room |
| OMR | Orbiter Management Review |
| OMRB | Operating Material Review Board |
| OMRC | Operational Maintenance Requirements Catalog |
| OMRF | Orbiter Modification And Refurbishment Facility |
| OMRP | Operations And Maintenance Requirements Plan |
| OMRSD | Document |
| OMRSD | O&M Requirements And Specifications Documentation |
| OMRSD | Operational Maintainability Reporting Systems Document |
| OMRSD | Operational Maintenance Requirements And Specification |
| OMS | Orbital Maneuvering Subsystem |
| OMS | Orbital Maneuvering System |
| OMSF | Office Of Manned Space Flight (now OSTS) |
| OMSP | Operational Maintenance Support Plan |
| OMU | Optical Measuring Unit |
| OMV | Oxygen Manual Valve |
| ONBD | Onboard |
| ONBT | Orbiter Neutral Buoyancy Trainer |
| OND | Operator Need Date |
| ONR | Office Of Naval Research |
| OOD | OrbiterOn-Dock |
| OODP | Out-of-Detent Pitch |
| OODR | Out-of-Detent Roll |
| OOMM | Organizational Operations And Maintenance Manual |
| OOP | Out Of Position |
| OOS | On-Orbit Station |
| OOS | Orbit-to-Orbit Shuttle |
| OOS | Orbit-to-Orbit Stage |
| OOSDP | On-Orbit Station Distribution Panel |
| OOT | Out Of Tolerance |
| OP | Open |
| OP | Operate |
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