| Acronym | Meaning |
| VHL | Von-Hippel Lindau |
| VHMS | Volcanic-hosted Massive Sulfide |
| VHSIC | Very High Speed Integrated Circuit |
| VIC | Vapor Injection Cure |
| VICAR | Visual Colorimeter For Atmospheric Research |
| VICIM | Virtual Institute For Chemometrics And Industrial Metrology |
| VIF | Valency-point Interaction Formula (in Graph Theory With At. And Mol. Orbitals) |
| VIM | Vacuum Induction Melting |
| VIM | Video-intensified Microscopy |
| VIMOS | VIsible MultiObject Spectrograph |
| VIMOX | Volume Identical Metal Oxidation |
| VIMS | Visible And IR Mapping Spectrometer |
| VIP | Vasoactive Intestinal Peptide |
| VIP | Vibronic Impact Parameter (model For Mol. Scattering) |
| VIRTIS | Visual IR Spectral And Thermal Spectrometer |
| VISITT | Vendor Information System For Innovative Treatment Technology (US EPA) |
| VISTTA | Visibility Impairment From Sulfur Transformation And Transport In The Atmosphere |
| VIVAH | Vibrational Variational Hyperspherical (for Mol. Calcns.) |
| VLA | Very Large Array |
| VLBA | Very Long Baseline Array |
| VLBI | Very Long Baseline Interferometry |
| VLC | Visible Light-cured |
| VLDL | Very Low Density Lipoprotein |
| VLDPE | Very Low Density Polyethylene |
| VLE | Vapor-liquid Equilibrium |
| VLF | Very Low Frequency (radiowaves) |
| VLG | Varying Localized Geminal |
| VLHC | Very Large Hadron Collider |
| VLP | Virus-like Particle |
| VLSI | Very Large-scale Integration |
| VLSIPS | Very Large Scale Immobilized Polymer Synthesis |
| VLT | Very Large Telescope |
| VLTI | Very Large Telescope Interferometer |
| VLWIR | Very Long Wavelength IR |
| VMAT | Vesicular Monoamine Transporter |
| VMC | Variational Monte Carlo (quantum Calcn. Method) |
| VMD | Vacuum Membrane Distillation |
| VMD | Vector Meson Dominance |
| VMD | Volumetric Mean Diameter (particulate Air Pollution) |
| VMO | Virtual Molecular Orbital |
| VMR | Vol. Mixing Ratio |
| VMS | Vehicle Management System |
| VMS | Volcanogenic Massive Sulfide |
| VMT | Vehicle Miles Traveled |
| VNS | Vicarious Nucleophilic Substitution |
| VNTR | Variable No. Of Tandem Repeat |
| VO | Valence Orbital |
| VO | Virtual Orbital |
| VO/CI | Virtual Orbital/configuration Interaction |
| VOA | Variable Optical Attenuator |