| Acronym | Meaning |
| SBS | Society For Biomolecular Screening |
| SBS | Sick Building Syndrome |
| SBS | Stimulated Brillouin Scattering |
| SBSL | Single-bubble Sonoluminescence |
| SBSR | Single Bead String Reactor |
| SBTT | Small Business Technology Transfer |
| SBUV | Solar Backscatter UV Instrument |
| SBZ | Surface Brillouin Zone |
| SC | Surface Capacitance |
| SC-1 | Standard Clean Solution #1 |
| SC-2D | State-correlated Two-dimensional (NMR Spectroscopy) |
| SC-FLAPW | Self-consistent Full-potential Linearized-augmented-plane-wave |
| SC-HL | Self-consistent Heitler-London |
| SC-MBPT | Single-configuration Many-body Perturbation Theory |
| SC-MEH-MO | Self-consistent-modified Extended Hueckel-MO |
| SC-OFMSW | Separately-collected Organic Fraction Of Municipal Solid Waste |
| SC-RPA | Single-channel Random Phase Approximation |
| SC-SCF | Semiclassical Self-consistent Field |
| SC-SEA | Single-channel Static-exchange Approximation |
| SC-SI | Semiclassical State Interaction (method For Solving Schroedinger Equation) |
| SC-VB | Spin-coupled Valence Bond |
| SCA | Specific Collection Areas |
| SCA | Standing Committee Of Analysts [probably Of EC] |
| SCA | Self-consistent Approximation |
| SCA | Semiclassical Approximation |
| SCA | Semiclassical Coulomb Approximation |
| SCA-QD-MBPT | Self-consistently Adapted (core Reference State) Quasidegenerate Many-body Perturbation Theory |
| SCAB | South Coast Air Basin |
| SCADA | Supervisory Control And Data Acquisition |
| SCADS | Superfund Chemical Analysis Data System (see CARD) |
| SCAF | Self-consistent Anisotropic Field |
| SCAG | Southern California Association Of Governments |
| SCAIS | Simulation Code For Atm. IR Spectra |
| SCALE | Symmetrically Configured AC Light Emitting [device] |
| SCALPEL | Scattering With Angular Limitation Projection Electron Lithography |
| SCALPEM | Scanning Laser Photoelectrochemical Microscopy |
| SCAMPI | Statistical Classification Of Activities Of Molecules For Pharmacophore Identification |
| SCAN | Silica-coated Aluminum Nitride |
| SCANIIR | Surface Composition Analysis By Neutral And Ion Impact Radiation |
| SCAP | Self-consistent Average Phonon (theory) |
| SCAP | Superfund Compliance Accomplishments Plan |
| SCAPS | Site Characterization And Analysis Penetrometer System |
| SCAQMD | South Coast Air Quality Management District |
| SCAQS | Southern California Air Quality Study |
| SCAR | Scientific Committee On Antarctic Research |
| SCAS | Stability And Command Augmentation System |
| SCASA | Semiclassical Approxn. Separated Atom |
| SCATE | Sulfur Chemistry In The Antarctic Troposphere Experiment |
| SCATMES | Scanning Camera And Target Measurement System |
| SCAUA | Semiclassical Approxn. United Atom |