| Acronym | Meaning |
 | ECA | Earth-crossing Asteroids |
| ECAO | Environmental Criteria And Assessment Office |
| ECCN | Export Control Classification Number |
| ECG | Environmental Coordinating Group |
| ECHAM4 | European Center HAMburg 4 |
| ECMOP | Experimental Center For Mesoscale Ocean Predictions |
| ECMRWF | European Centre For Medium-Range Weather Forecasts |
| ECMWF | European Centre For Medium-range Weather Forecasting |
| ECN | Energy Research Foundation |
| ECOD | Export Control Operations Division |
| ECP | Engineering Change Proposal |
| ECR | Economic Cleanup Responsibility Act |
| ECR | Engineering Change Request |
| ECS | EOSDIS Core System |
| ECSA | Early Career Scientists Assembly |
| ECTD | Emission Control Technology Division |
| ECU | Environmental Crimes Unit |
| EDA | Ecosystem Dynamics And The Atmosphere |
| EDAS | Ecosystem Dynamics And The Atmosphere Section |
| EDC | EROS Data Center |
| EDF | Exploratory Development Facility |
| EDF/ DER | Electricit? De France/ Direccion Des Etudes Et Recherche |
| EDMS | Electra Data Management System |
| EDP | Electronic Data Processing |
| EDP | Embedded Data Processor |
| EDRS | European Data Relay Satellite |
| EDS | Environmental Data Service |
| EDS | Electronic Data Systems |
| EDUCOM | A Consortium Of Industrial Organizations And University Computing Administrators |
| EEA | European Environment Agency |
| EEC | European Economic Community |
| EECF | Earthnet ERS-1 Central Facility |
| EED | Exposure Evaluation Division |
| EEI | Edison Electric Institute |
| EEID | EOSDIS External Interface Document |
| EEMD/NV | Engineering And Energy Management |
| EEMOC | European EMOC |
| EEOC | Equal Employment Opportunity Commission |
| EEPROM | Electronically Eraseable And Programmable Read Only Memory |
| EERL | Eastern Environmental Radiation Lab |
| EERU | Environmental Emergency Response Unit |
| EES | Earth & Environmental Science |
| EESI | Environment & Energy Study Institute |
| EETFC | Environmental Effects |
| EEZSCAN | Exclusive Economic Zone Scan |
| EF | Error Function |
| EF | Emission Factor |
| EFC | Experimental Forecast Center |
| EFEDA | European Field Experiment In Desertification-Threatened Area |
| EFF | Experimental Forecast Facility |
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