| Acronym | Meaning |
 | DSCS | Defense Satellite Communications System |
| DSN | Deep Space Network |
| DSO | Detailed Supplementary Objective |
| DSP | Defense Support Program |
| DSS | Deep Space Station |
| DSSC | Deep Space Station Complex |
| E | Elliptical (for Galaxies) |
| EAFB | Edwards Air Force Base |
| ECS | Environmental Control System |
| EDC | EROS Data Center |
| EDO | Extended Duration Orbiter |
| EDOMP | EDO Medical Project |
| EDRS | European Data Relay Satellite |
| EDS | Electronic Data Systems |
| EGRET | Energetic Gamma Ray Experiment Telescope |
| EJASA | Electronic Journal Of The Astronomical Society Of The Atlantic |
| ELDO | European Launcher Development Organisation |
| ELV | Expendable Launch Vehicle |
| EMU | Extravehicular Mobility Unit |
| ENAC | Energetic Neutral Atom Camera |
| ENACEOS | ENAC For EOS |
| ENAP | Energetic Neutral Atom Precipitation |
| ENSO | El Nino/Southern Oscillation |
| EODC | Earth Observation Data Centre |
| EOS | Earth Observing System |
| EOS | Electrophoresis Operations In Space |
| EOSP | Earth Observing Scanning Polarimeter |
| EPD | Energetic Particles Detector |
| ER | Eastern Range |
| ERBE | Earth Radiation Budget Experiment |
| EROS | Earth Resources Observations System |
| ERS | Earth Resources Satellite |
| ERS | European Remote Sensing |
| ERS | Environmental Research Satellite |
| ESA | European Space Agency |
| ESIS | European Space Information System |
| ESO | European Southern Observatory |
| ESOC | European Space Operations Centre |
| ESPC | European Space Power Conference |
| ESRIN | European Space Research Institute |
| ESRO | European Space Research Organisation |
| ESTEC | European Space Research And Technology Centre |
| ET | External Tank |
| ET | Ephemeris Time |
| ETE | End-to-End |
| ETM | Enhanced Thematic Mapper |
| ETR | Eastern Test Range |
| EUMETSAT | European Meterological Satellite Organisation |
| EURECA | European Retrievable Carrier |
| EUTELSAT | European Telecommunications Satellite Organization |
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