| Acronym | Meaning |
 | A/L | Air Lock |
| AAFE | Aeroassist Flight Experiment |
| ABCL | As Built Configuration List |
| ABHRS | As Built Hardware Reporting System |
| AC | Alternating Current |
| AC | Comptroller Office |
| ACES | Acoustic Containerless Experiment System |
| ACIP | Assembly Configuration And Integration Panel |
| ACR | Active Cavity Radiometer |
| ACRBC | Acceptance |
| ACRC | Assured Crew Return Capability - Now ACRV |
| ACRIM | Active Cavity Radiometer Irradiance Monitor |
| ACRV | Assured Crew Return Vehicle |
| ACTS | (TOS) Advanced Communications Technology Satellite |
| AD | Aperture Door |
| ADC | Affiliated Data Center |
| ADEOS | Advanced Earth Observing Mission |
| ADP | Acceptance Data Package |
| ADP | Automated Data Processing |
| ADPS | Acceptance Data Package System |
| ADSF | Advanced Directional Solidification Furnace |
| AEG | AEG Telefunken |
| AEPI | Atmospheric Emissions Photo Imaging |
| AES | Atmospheric Exchange System |
| AESE | Airborne Electrical Support Equipment |
| AFB | Air Force Base |
| AFD | Aft Flight Deck |
| AFE | American Flight Echocardiograph |
| AFP | Air Force Program |
| AFR | Air Force Regulation |
| AFSCF | Air Force Satellite Control Facility |
| AFTA | Aft Frame Tilt Actuator |
| AFTE | Autogenic Feedback Training Experiment |
| AGOSS | Automated Ground Operations Scheduling System |
| AHU | Air Handling Unit |
| AI | Artificial Intelligence |
| AIRS | Atmospheric Infrared Sounder |
| AIT | Aeritalia |
| ALAE | Atmospheric Lyman Alpha Experiment |
| ALC | Augmented Landing Site |
| ALERT | Acute Launch Emergency Reliability Tip |
| ALRUTS | Automated Line Replaceable Unit Tracking System |
| ALS | Advanced Launch System |
| ALT | Altimeter |
| AMF | Astronaut Memorial Foundation |
| AMSU | Advanced Microwave Sounding Unit |
| ANSI | American National Standard Institute |
| AO | Assembly Order |
| AOA | Abort Once Around |
| APC | Adaptive Payload Carrier |
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