| Acronym | Meaning |
 | SD | Sindhi Language (ISO 639-1 Code) |
| SDC | Shaft Driven Compressor - U.S. Army Strategic Defense Command (1985?1992) |
| SDG | Sudanese Pound (ISO 4217 Currency Code) |
| SDH | Synchronous Digital Hierarchy |
| SDI | See Entry |
| SDN | Sudan (ISO 3166 Trigram) |
| SDO | Scattered Disc Object |
| SDP | Social Democratic Party (European Politics) |
| SDR | Strategic Defence Review |
| SDRAM | Synchronous Dynamic Random-Access Memory (ess-dee-ram) |
| SDS | Students For A Democratic Society |
| SDSS | Sloan Digital Sky Survey |
| SE | Northern Sami Language (ISO 639-1 Code) |
| SE | Selenium |
| SE | Seychelles (FIPS 10-4 Country Code) - South-East - Sweden (ISO 3166 Digram) -Synthetic Environment - System Engineering |
| SEAD | Suppression Of Enemy Air Defence |
| SEADI | Senior Executioner Of Approved Driving Instructors |
| SEAFDEC | Southeast Asian Fisheries Development Center |
| SEAL | SEa-Air-Land |
| SEATO | Southeast Asian Treaty Organization |
| SEAWIFS | Sea-Viewing Wide Field Of View Sensor (satellite Instrument) |
| SEC | U.S. Securities And Exchange Commission -Security - Southeastern Conference |
| SECAM | S?quentiel Couleur ? M?moire (French For Colour Sequential With Memory; TV Standard |
| SECDEF | (U.S.) Secretary Of Defense |
| SED | CERDEC Software Engineering Directorate |
| SEDRIS | Synthetic Environment Data Representation And Interchange Specification |
| SEE | Small Emplacement Excavator |
| SEG | Society Of Exploration Geophysicists |
| SEG | Special Escort Group |
| SEK | Swedish Krona (ISO 4217 Currency Code) |
| SEM | Sensor Employment Manager |
| SEN | Senegal (ISO 3166 Trigram) -Small Extension Node |
| SEP | Somebody Else's Problem - Spherical Error Probable - System Enhancement Package - System Engineering Plan |
| SERE | Survival |
| SESSPE | Submarine Escape And Surface Survival Personnel Equipment |
| SET | Staphylococcal EnteroToxin |
| SETAC | Society For Environmental Toxicology And Chemistry |
| SETI | Search For ExtraTerrestrial Intelligence |
| SEU | Single Event Upset (solid State Physics) - Slightly Enriched Uranium - Special Evidence Unit |
| SF | Fleet Submarine (retired US Navy Hull Classification) -San Francisco - Science Fiction -South Africa (FIPS 10-4 Country Code) -Speculative Fiction - Special Forces |
| SF&F | Science Fiction & Fantasy |
| SFE | Supercritical Fluid Extraction - Sydney Futures Exchange |
| SFF | Standard File Format |
| SFOB | Special Forces Operations Base |
| SFOR | UN Stabilisation Force (in Bosnia And Herzegovina) |
| SFU | Simon Fraser University (Canada) |
| SG | Sango Language (ISO 639-1 Code) |
| SG | Seaborgium |
| SG | Senegal (FIPS 10-4 Country Code) - Singapore (ISO 3166 Digram) - Snow Grains (METAR Code) -Study Group |
| SGC | Server Gated Cryptography -Stargate Command |
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