| Acronym | Meaning |
 | CTDB | Compact Terrain Data Base (file Format) |
| CTE | Canton And Enderbury Islands (ISO 3166 Trigram; Obsolete 1984) |
| CTGF | Connective Tissue Growth Factor |
| CTI | Co-operative Target Identification |
| CTIL | Critical Tracked Items List |
| CTIS | Central Tire-Inflation System |
| CTMS | Clinical Trial Management System |
| CTO | Chief Technical Officer - Chief Technology Officer |
| CTS | Clear-To-Send - Collective Training Standards - Communications Technology Service - Contract Technical Services - Conversation Time Sharing - COSMIC Top Secret |
| CTSS | Compatible Time-Sharing System |
| CTU | Counter Terrorist Unit (fictional Branch Of The Central Intelligence Agency In The Television Action Series 24) |
| CTVT | Canine Transmissible Venereal Tumour |
| CU | Copper (Latin Cuprum) |
| CU | Cuba (FIPS 10-4 Country Code; ISO 3166 Digram) |
| CU | Old Church Slavonic Language (ISO 639-1 Code) |
| CUB | Cuba (ISO 3166 Trigram) |
| CUCV | Commercial Utility Cargo Vehicle |
| CUNT | Chief Utiliser Of Novel Technologies |
| CUNY | City University Of New York (CUE-knee) |
| CUP | Cuban Peso (ISO 4217 Currency Code) |
| CUPE | Canadian Union Of Public Employees (CUE-pee) |
| CUPS | Common Unix Printing System |
| CUPW | Canadian Union Of Postal Workers |
| CUREA | Consortium For Undergraduate Research And Education In Astronomy |
| CV | Chuvash Language (ISO 639-1 Code) |
| CV | Many |
| CVCC | Combat Vehicle Command And Control |
| CVE | Cape Verde Escudo (ISO 4217 Currency Code) |
| CVI | Combat Vehicle Identification |
| CVLL | Crypto Variable Logic Label |
| CVR | Cockpit Voice Recorder - Combat Vehicle Reconnaissance |
| CVR(T) | Combat Vehicle Reconnaissance (Tracked) |
| CVS | Concurrent Versions System |
| CVSD | Continuous Variable Slope Delta (modulation) |
| CVT | Continuously Variable Transmission |
| CW | Continuous Wave (laser) -Cook Islands (FIPS 10-4 Territory Code) |
| CWC | Chemical Weapons Convention |
| CWRU | Case Western Reserve University |
| CWS | Canadian Wildlife Service |
| CX | Christmas Island (ISO 3166 Digram) - One Hundred And Ten (in Roman Numerals) |
| CXR | Christmas Island (ISO 3166 Trigram) |
| CY | Calendar Year -Cyprus (ISO 3166 And FIPS 10-4 Country Code Digram) |
| CY | Welsh Language (ISO 639-1 Code) |
| CYM | Cayman Islands (ISO 3166 Trigram) |
| CYM | Welsh Language (ISO 639-2 Code) |
| CYP | Cyprus (ISO 3166 Trigram) - Cyprus Pound (ISO 4217 Currency Code) |
| CZ | Combat Zone -Czech Republic (ISO 3166 And FIPS 10-4 Country Code Digram) |
| CZE | Czech Republic (ISO 3166 Trigram) |
| CZK | Czech Koruna (ISO 4217 Currency Code) |
| CZMA | (US) Coastal Zone Management Act |
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