| Acronym | Meaning |
 | CJTF | Combined Joint Task Force |
| CK | Cocos (Keeling) Islands (FIPS 10-4 Country Code) - Cook Islands (ISO 3166 Digram) |
| CKA | Canada Kicks Ass |
| CKND | Codename: Kids Next Door |
| CL | Chile (ISO 3166 Digram) -Co-ordination Line - One Hundred And Fifty (in Roman Numerals) |
| CL | Chlorine |
| CLEC | Competitive Local Exchange Carrier |
| CLEMARS | California Law Enforcement Mutual Aid Radio System |
| CLI | Command Line Interface/Interpreter |
| CLIC | Compact LInear Collider |
| CLO | Cornell Lab Of Ornithology |
| CLOB | Character Large OBject |
| CLOS | Common Lisp Object System |
| CLOS | Command To Line-Of-Sight (missile Control System) |
| CLP | Chilean Peso (ISO 4217 Currency Code) -Common [Operating/Operational] Land Picture |
| CLPFC | CentroLateral PreFrontal Cortex |
| CLRP | College Loan Repayment Program |
| CM | Cameroun (FIPS 10-4 Country Code; ISO 3166 Digram) -Cruise Missile -Nine Hundred (in Roman Numerals) |
| CM | Curium |
| CMA | U.S. Chemical Materials Agency |
| CMB | Cosmic Microwave Background |
| CMBR | Cosmic Microwave Background Radiation |
| CME | Coronal Mass Ejection (usually Sun) |
| CMHC | Canada Mortgage And Housing Corporation |
| CMJ | Christopher Martin-Jenkins (BBC Sports Commentator) |
| CML | Chemical -Chronic Myelogenous Leukemia (formerly Chronic Myeloid Leukemia) |
| CMM | Capability Maturity Model |
| CMMC | Corps Materiel Management Centre |
| CMML | Chronic MyeloMonocytic Leukemia |
| CMO | Civil-Military Operations |
| CMOC | Civil-Military Operations Centre |
| CMOS | Canadian Meteorological And Oceanographic Society - Complementary Metal-Oxide-Semiconductor |
| CMP | Common [Operating/Operational] Maritime Picture |
| CMPD | Charlotte Mecklenburg Police Department |
| CMPD | Chronic Myeloproliferative Disease |
| CMR | Cameroon (ISO 3166 Trigram) -Coaxial Main Rotors (helicopter Type) |
| CMS | Centres For Medicare And Medicaid Services |
| CMYK | Cyan Magenta Yellow Key/blacK (colour Model) |
| CN | Canadian National (railway) -China (ISO 3166 Digram) - Comoros (FIPS 10-4 Country Code) |
| CNA | Center For Naval Analyses - Certified Network Administrator - Computer Network Attack |
| CND | Campaign For Nuclear Disarmament - Computer Network Defence |
| CNE | Canadian National Exhibition - Computer Network Exploitation - Certified Network Engineer |
| CNI | Communications |
| CNN | Cable News Network - Cellular Nonlinear Network |
| CNO | Computer Network Operations |
| CNR | Canadian National Railway - Combat Net Radio |
| CNV | Copy-Number Variable (genetics) |
| CNY | Chinese Yuan Renminbi (ISO 4217 Currency Code) |
| CO | Cobalt |
| CO | Corsican Language (ISO 639-1 Code) |
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