| Acronym | Meaning |
| SMB | Suck My Balls |
| SME | Subject Matter Expert |
| SME1 | Some One |
| SMEM | Send Me E-Mail |
| SMH | Shaking My Head |
| SMIM | Send Me An Instant Message |
| SMOP | Small Matter Of Programming |
| SNAFU | Situation Normal, All F*cked Up |
| SNAG | Sensitive New Age Guy |
| SNERT | Snotty Nosed Egotistical Rotten Teenager |
| SO | Significant Other (spouse, Boyfriend / Girlfriend) |
| SOB | Son Of A B*tch |
| SOBT | Stressed Out Big Time |
| SOGOP | Sh*t Or Get Off The Pot |
| SOH | Sense Of Humor |
| SOHF | Sense Of Humor Failure |
| SOI | Self Owning Idiot |
| SOIAR | Sit On It And Rotate |
| SOL | Sh*t Out Of Luck |
| SOMY | Sick Of Me Yet |
| SOOYA | Snake Out Of Your Ass |
| SOP | Standard Operating Procedure |
| SORG | Straight Or Gay |
| SOS | Same Old Sh*t |
| SOSDD | Same Old Sh*t, Different Day |
| SOT | Short On Time |
| SOTMG | Short On Time, Must Go |
| SOW | Speaking Of Which |
| SOZ | Sorry |
| SRO | Standing Room Only |
| SRSLY | Seriously |
| SRY | Sorry |
| SSC | Super Sexy Cute |
| SSDD | Same Sh*t, Different Day |
| SSEWBA | Someday Soon, Everything Will Be Acronyms |
| SSIA | Subject Says It All |
| STBY | Sucks To Be You |
| STD | Seal The Deal |
| STD | Sexually Transmitted Disease |
| STFU | Shut The F*ck Up |
| STFW | Search The F*cking Web |
| STM | Spank The Monkey |
| STPPYNOZGTW | Stop Picking Your Nose, Get To Work |
| STR8 | Straight |
| STS | So To Speak |
| STW | Search The Web |
| STYS | Speak To You Soon |
| SU | Shut Up |
| SUAC | Sh*t Up A Creek |
| SUAKM | Shut Up And Kiss Me |