| Acronym | Meaning |
 | SAHM | Stay At Home Mom |
| SAIA | Stupid Asses In Action |
| SAPFU | Surpassing All Previous Foul / F*ck Ups |
| SB | Stand By |
| SBI | Sorry 'Bout It |
| SBTA | Sorry, Being Thick Again |
| SBUG | Small Bald Unaudacious Goal |
| SC | Stay Cool |
| SCNR | Sorry, Could Not Resist |
| SDK | Scottie Doesn't Know (reference To Star Trek |
| SDK | Software Developer's Kit |
| SEC | Wait A Second |
| SED | Said Enough Darling |
| SEG | Sh*t Eating Grin |
| SEP | Somebody Else's Problem |
| SETE | Smiling Ear To Ear |
| SEWAG | Scientifically Engineered Wild Ass Guess |
| SF | Science Fiction |
| SF | Surfer Friendly |
| SFAIAA | So Far As I Am Aware |
| SFETE | Smiling From Ear To Ear |
| SFLA | Stupid Four Letter Acronym |
| SFTTM | Stop F*cking Talking To Me |
| SFX | Sound Effects |
| SFX | Stage Effects |
| SH | Sh*t Happens |
| SHB | Should Have Been |
| SHID | Slap Head In Disgust |
| SHMILY | See How Much I Love You |
| SIC | Spelling Is Correct |
| SICL | Sitting In Chair Laughing |
| SICS | Sitting In Chair Snickering |
| SII | Seriously Impaired Imagination |
| SIL | Sister-In-Law |
| SIP | Skiing In Powder |
| SIT | Stay In Touch |
| SITCOM | Single Income, Two Children, Oppressive Mortgage |
| SITD | Still In The Dark |
| SIUP | Suck It Up Pussy |
| SIUYA | Shove It Up Your Ass |
| SK8R | Skater |
| SL | Second Life |
| SLAP | Sounds Like A Plan |
| SLAW | Sounds Like A Winner |
| SLIRK | Smart Little Rich Kid |
| SLM | See Last Mail |
| SLOM | Sticking Leeches On Myself |
| SLT | Something Like That |
| SM | Senior Moment |
| SMAIM | Send Me An Instant Message |
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