| Acronym | Meaning |
 | MCPC | Manipulator Controller Power Conditioner |
| MCPS | Major Cost Proposal System |
| MCR | Master Change Record |
| MCS | Maintenance And Checkout Station |
| MCS | Measurements Calibration System |
| MCT | Maximum Climb Thrust |
| MCT | Mission Control Table |
| MCU | Master Control Unit |
| MCU | Mission Control Unit |
| MCVP | Materials Control And Verification Program |
| MCW | Modulated Continuous Wave |
| MD | Biomedical Office (KSC Directorate) |
| MD | MalfunctionDetection |
| MD | Manual Direct |
| MD | Manual Disconnect |
| MD | Master Dimension |
| MD | Microdot |
| MD | Mission Director |
| MDA | Main Distribution Assembly |
| MDA | Maintainability Design Approach |
| MDA | Middeck Assembly (FDF) |
| MDA | Motor Drive Amplifier |
| MDA | Multiple Docking Adapter |
| MDAC | McDonnell Douglas Astronautics Company |
| MDAR | Malfunction Detection |
| MDAS | Meteorological Data Acquisition System |
| MDAS | Mission Data Acquisition System |
| MDB | Mission Data Book |
| MDC | Main Display Console |
| MDC | Mission Director Center |
| MDC | Mission Duty Cycle |
| MDCA | Main Distribution Control Assembly |
| MDCS | Maintenance Data Collection System |
| MDCS | Malfunction Display And Control System |
| MDCS | Master Digital Command System |
| MDCS | Material Data Collection System |
| MDD | Mate/Demate Device |
| MDD | Mate/demate Device |
| MDDS | Material Directory Data Sheet |
| MDE | Mission Dependent Equipment |
| MDE | Mission Dependent Experiment |
| MDE | Modular Display Electronics |
| MDF | Main Distribution Frame |
| MDF | Manipulator Development Facility |
| MDF | Mating/Demating Facilities |
| MDF | Mild Detonating Fuse |
| MDF | Mild Detonating Fuse |
| MDL | Master Data Library |
| MDM | Manipulator Deployment Mechanism |
| MDM | Medical Monitor |
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